Effect of blueberry intervention on endothelial function: a systematic review and meta-analysis
Deng B, Lei Y, Zhou R, Ruan T, Lu W, Ying J, Yue Y, Mu D
Frontiers in physiology · 9 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (81971428); National Natural Science Foundation of China (81971433); National Natural Science Foundation of China (82371717); National Natural Science Foundation of China (82201905); National Natural Science Foundation of China (2021YFC2701700); National Natural Science Foundation of China (82271749)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-06-03 · Front Physiol · vol. 15 · pág. 1368892
- Editorial
- Frontiers Media
- Citado
- 11 citas · más que el 80% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Blood Pressure and Hypertension Studies · Cardiovascular Health and Disease Prevention · Sodium Intake and Health
- Palabras clave
- Medicine, Blood pressure, Internal medicine, Endothelial dysfunction, Meta-analysis, Confidence interval, Population, Cochrane Library, Reactive hyperemia, Cardiology, Endocrinology, Blood flow
8 autores
- Bixin Deng🇨🇳Sichuan University; West China Second University Hospital of Sichuan University
- Yupeng Lei🇨🇳Sichuan University; West China Second University Hospital of Sichuan University
- Ruixi Zhou🇨🇳Sichuan University; West China Second University Hospital of Sichuan University
- Tiechao Ruan🇨🇳Sichuan University; West China Second University Hospital of Sichuan University
- Wenting Lu🇨🇳Sichuan University; West China Hospital of Sichuan University
- Junjie Ying🇨🇳Sichuan University
- Yan Yue🇨🇳 · autor de correspondenciaSichuan University; West China Second University Hospital of Sichuan University
- Dezhi Mu🇨🇳 · autor de correspondenciaSichuan University; West China Second University Hospital of Sichuan University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction: Endothelial dysfunction indicates blood vessel injury and is a risk factor for cardiovascular diseases. Blueberry has been approved for its benefits on human health, especially on cardiovascular function. However, its effect on endothelial function remains unclear. We conducted a systematic review and meta-analysis to explore the impact of blueberries on endothelial function in adults. Methods: We searched PubMed, Web of Science, Embase, and the Cochrane Library, 16 studies were included in the systematic review, and 11 were used for the meta-analysis. Data associated with endothelial function were extracted and pooled as mean differences (MD) with 95% confidence intervals (CI). Results: Blueberry consumption significantly improved flow-mediated dilation (FMD) by 1.50% (95% CI: 0.81, 2.20; I2 = 87%) and reactive hyperemia index (RHI) by 0.26 (95% CI: 0.09, 0.42; I2 = 72%). A significant decrease in diastolic blood pressure (DBP) was also observed (MD: -2.20 mm Hg; 95% CI: -4.13, -0.27; I2 = 11%). Subgroup analysis indicated a significant decrease in blood pressure (Systolic blood pressure [SBP]: -3.92 mmHg; 95% CI: -6.88, -0.97; I2 = 20% and DBP: -2.20 mmHg; 95% CI: -4.13, -0.27; I2 = 11%) in the smoking population. However, SBP levels (MD: -1.43 mm Hg; 95% CI: -3.11, 0.26; I2 = 20%) and lipid status (high-density lipoprotein cholesterol [HDL-C]: 0.06; 95% CI: -0.04, 0.16; I2 = 77%; low-density lipoprotein cholesterol [LDL-C]: 0.05; 95% CI: -0.14, 0.24; I2 = 0%) did not significantly improve. Conclusion: Blueberry intervention improved endothelial function and DBP. Subgroup analysis revealed a notable improvement in blood pressure among the smoking population. However, no significant effects were observed on SBP, HDL-C, and LDL-C levels. Future research should delve into the mechanisms of endothelial improvement and verify blood pressure reduction in specific subpopulations through large-scale trials. Clinical Trial Registration: https://www.crd.york.ac.uk/PROSPERO/, Identifier CRD42023491277.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.