Brain responses to intermittent fasting and the healthy living diet in older adults
Kapogiannis D, Manolopoulos A, Mullins R, Avgerinos K, Delgado-Peraza F, Mustapic M, Nogueras-Ortiz C, Yao PJ, Pucha KA, Brooks J, Chen Q, Haas SS, Ge R, Hartnell LM, Cookson MR, Egan JM, Frangou S, Mattson MP
Cell metabolism · 44 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Aging
- Gobierno
- National Institute of Mental Health
- Gobierno
- Intramural NIH HHS
- Gobierno
- NIMH NIH HHS
- Subvenciones
- National Institute of Mental Health (T32 MH122394); National Institutes of Health (Z99 AG999999); National Institutes of Health (ZIA AG000966); National Institute on Aging (ZIAAG000975)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2024-06-19 · Cell Metab · vol. 36 · número 8 · págs. 1668–1678.e5
- Editorial
- Cell Press
- Citado
- 60 citas · más que el 99% de estudios similares · 14.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 98 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Dietary Effects on Health · Nutritional Studies and Diet · Dementia and Cognitive Impairment Research
- Palabras clave
- intermittent fasting, 5:2 diet, brain health, older adults, insulin resistance, insulin signaling, extracellular vesicles, brain aging, brain glucose, cognitive function, executive function, memory, Alzheimer's disease biomarkers, cerebrospinal fluid, weight loss, apolipoprotein E, sex differences, genetic moderators
- MeSH
- brain, humans, insulin resistance, magnetic resonance imaging, cognition, aged, middle aged, female, male, biomarkers, diet, healthy, intermittent fasting
18 autores
- Dimitrios Kapogiannis🇺🇸 · autor de correspondenciaJohns Hopkins University; National Institute on Aging
- Apostolos Manolopoulos🇺🇸National Institute on Aging
- Roger J. Mullins🇺🇸Morgan State University
- Konstantinos Ioannis Avgerinos🇺🇸Wayne State University
- Francheska Delgado‐Peraza🇺🇸National Institute on Aging
- Maja Mustapić🇺🇸National Institute on Aging
- Carlos J. Nogueras‐Ortiz🇺🇸National Institute on Aging
- Pamela J. Yao🇺🇸National Institute on Aging
- Krishna Ananthu Pucha🇺🇸National Institute on Aging
- Janet A. Brooks🇺🇸National Institutes of Health; National Institute on Aging
- Qinghua Chen🇺🇸National Institute on Aging
- Shalaila S. Haas🇺🇸Icahn School of Medicine at Mount Sinai
- Ruiyang Ge🇨🇦University of British Columbia
- Lisa M. Hartnell🇺🇸National Institute on Aging
- Mark Cookson🇺🇸National Institutes of Health; National Institute on Aging
- Josephine Mary Egan🇺🇸National Institute on Aging
- Sophia Frangou🇨🇦🇺🇸University of British Columbia; Icahn School of Medicine at Mount Sinai
- Mark P. Mattson🇺🇸Johns Hopkins University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Diet may promote brain health in metabolically impaired older individuals. In an 8-week randomized clinical trial involving 40 cognitively intact older adults with insulin resistance, we examined the effects of 5:2 intermittent fasting and the healthy living diet on brain health. Although intermittent fasting induced greater weight loss, the two diets had comparable effects in improving insulin signaling biomarkers in neuron-derived extracellular vesicles, decreasing the brain-age-gap estimate (reflecting the pace of biological aging of the brain) on magnetic resonance imaging, reducing brain glucose on magnetic resonance spectroscopy, and improving blood biomarkers of carbohydrate and lipid metabolism, with minimal changes in cerebrospinal fluid biomarkers for Alzheimer's disease. Intermittent fasting and healthy living improved executive function and memory, with intermittent fasting benefiting more certain cognitive measures. In exploratory analyses, sex, body mass index, and apolipoprotein E and SLC16A7 genotypes modulated diet effects. The study provides a blueprint for assessing brain effects of dietary interventions and motivates further research on intermittent fasting and continuous diets for brain health optimization. For further information, please see ClinicalTrials.gov registration: NCT02460783.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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