Effect of Intermittent Fasting on Liver Function Tests: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Ranjbar M, Shab-Bidar S, Mohammadi H, Djafarian K
Nutrition reviews · 1 cita
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Tehran University of Medical Sciences and Health Services
- Universidad u hospital
- Tehran University of Medical Sciences
- Subvenciones
- Tehran University of Medical Sciences and Health Services (1402-1-212-65312); Tehran University of Medical Sciences and Health Services (IR.TUMS.MEDICINE.REC.1402.157)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2024-06-25 · Nutr Rev · vol. 83 · número 3 · págs. e965–e979
- Editorial
- Oxford University Press
- Citado
- 5 citas · más que el 50% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 52 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Liver Disease Diagnosis and Treatment · Enhanced Recovery After Surgery
- Palabras clave
- intermittent fasting, liver function tests, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, alkaline phosphatase, non-alcoholic fatty liver disease, liver enzymes
- MeSH
- liver, humans, alkaline phosphatase, gamma-glutamyltransferase, alanine transaminase, aspartate aminotransferases, liver function tests, randomized controlled trials as topic, intermittent fasting
4 autores
- Mahsa Ranjbar🇮🇷Tehran University of Medical Sciences
- Sakineh Shab‐Bidar🇮🇷Tehran University of Medical Sciences
- Hamed Mohammadi🇮🇷Tehran University of Medical Sciences
- Kurosh Djafarian🇮🇷 · autor de correspondenciaTehran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Intermittent fasting (IF) is a diet strategy with alternate intervals of calorie reduction and normal eating. Despite its beneficial effects on weight loss and cardiometabolic risk factors, the effect of IF on liver function tests (LFTs) remains unclear.
Objective
This study aimed to investigate the effect of IF on LFTs through a systematic review and meta-analysis of randomized clinical trials.
Data sources
An electronic search was performed using predefined search terms in databases including PubMed, Scopus, and ISI Web of Science until February 2023.
Data extraction
The studies were selected according to PRISMA guidelines, and the risk of bias was assessed for the randomized controlled trials.
Data analysis
The results of this study are reported as weighted mean differences (WMDs) with 95% CIs. Fourteen RCTs were included in the meta-analysis, with a total sample size of 908. IF significantly reduced alanine aminotransferase (ALT) (WMD: -2.88, 95% CI: -4.72 to -1.04, P-value = .002) and aspartate aminotransferase (AST) levels (WMD: -1.67, 95% CI: -3.12 to -0.22, P-value = .024). The results of the subgroup analysis showed that the impact of IF was significant in both the nonalcoholic fatty liver disease and the healthy groups for ALT. The effects of IF on the serum gamma-glutamyl transpeptidase (GGT) level were significant (WMD: -3.19, 95% CI: -6.00 to -0.39, P-value = .026), but there were no significant changes in the alkaline phosphatase (ALP) level (WMD: 1.06, 95% CI: -0.23 to 2.34, P-value = .106). Furthermore, no substantial heterogeneity between studies was reported.
Conclusion
IF can improve ALT, AST, and GGT levels but not ALP enzyme levels and may have a benefit on liver function.
Systematic review registration
PROSPERO registration no. CRD42023396211.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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