The interaction between estimated glomerular filtration rate and dietary magnesium intake and its effect on stroke prevalence: a cross-sectional study spanning 2003-2018
Liu C, Qiu L, Zhang Y, Chen L, Wang H, Lin H, Tao Y, Ye H
Frontiers in nutrition · 2 citas
Cómo se estudió
- Diseño
- Estudio transversal (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-06-11 · Front Nutr · vol. 11 · pág. 1395685
- Editorial
- Frontiers Media
- Citado
- 1 cita · más que el 48% de estudios similares · 0.2× el promedio de su campo
- Referencias
- 54 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Potassium and Related Disorders
- Palabras clave
- Medicine, Stroke (engine), Odds ratio, Renal function, National Health and Nutrition Examination Survey, Kidney disease, Internal medicine, Confidence interval, Cross-sectional study, Risk factor, Magnesium, Endocrinology, Environmental health, Population, Pathology, Chemistry
8 autores
- Chunhua Liu🇨🇳Lishui Central Hospital
- Linan Qiu🇨🇳Wenzhou Medical University; First Affiliated Hospital of Wenzhou Medical University
- Yuanyuan Zhang🇨🇳Lishui Central Hospital
- Liping Chen🇨🇳Lishui Central Hospital
- Huaqiang Wang🇨🇳Lishui Central Hospital
- Huajian Lin🇨🇳Lishui Central Hospital
- Yongjun Tao🇨🇳 · autor de correspondenciaLishui Central Hospital
- Haiqin Ye🇨🇳 · autor de correspondenciaWenzhou Medical University; First Affiliated Hospital of Wenzhou Medical University; Lishui Central Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Despite the known associations of dietary magnesium intake and estimated glomerular filtration rate (eGFR) with cardiovascular diseases, their combined effects on stroke risk remain unclear. Therefore, this study aims to explore the associations of dietary magnesium intake and eGFR with stroke risk.
Methods
The National Health and Nutrition Examination Survey (NHANES) data of 37,637 adult participants (≥18 years) from 2003 to 2018 was analyzed. Dietary magnesium intake was categorized as low (≤ 254 mg/day) and normal (> 254 mg/day) based on experimental data. Multiple logistic regression analyses and interaction tests were conducted to assess the associations of dietary magnesium intake and eGFR with stroke risk, with a focus on the interaction between different chronic kidney disease (CKD) stages based on eGFR levels and dietary magnesium intake. Additional analyses included multiplicative interaction analysis, restricted cubic spline analysis, and subgroup evaluations by age, sex, and ethnicity.
Results
Dietary magnesium intake and eGFR were inversely correlated with the risk of stroke. Participants with low dietary magnesium intake had a higher stroke risk than those with normal magnesium intake (odds ratio [OR] 1.09, 95% confidence interval [CI]: 1.03-1.42). Likewise, low eGFR was associated with an elevated stroke risk compared with normal eGFR (OR 1.56, 95% CI: 1.15-2.13). Furthermore, the two factors showed a multiplicative interaction effect on stroke risk (OR 1.05, 95% CI: 1.01-1.09). We observed a significant interaction between stage G3 CKD and low dietary magnesium intake (OR 1.05, 95% CI: 1.01-1.09), suggesting a potential association with stroke risk. However, similar associations were not observed for stages G4 and G5, possibly due to the smaller number of participants with G4 and G5 CKD. The restricted cubic spline analysis revealed a non-linear relationship between dietary magnesium intake, eGFR, and stroke risk. The interaction between magnesium deficiency and low eGFR persisted in participants aged >60 years, as well as in females, non-Hispanic Black people, and people of other races.
Conclusion
Dietary magnesium intake and eGFR correlate negatively with stroke prevalence. Moreover, there was an interaction between dietary magnesium intake and stroke prevalence across different CKD stages. Further large-scale prospective studies are needed to analyze the potential relationship between dietary magnesium intake, eGFR, and stroke.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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