Intermittent fasting and high-intensity interval training do not alter gut microbiota composition in adult women with obesity
Batitucci G, Almeida OG, De Martinis ECP, Solar I, Cintra DE, de Freitas EC
American journal of physiology. Endocrinology and metabolism · 10 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
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Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
- Subvenciones
- Fundação de Amparo à Pesquisa do Estado de São Paulo (19/01970-0); Fundação de Amparo à Pesquisa do Estado de São Paulo (22/15078-4); Conselho Nacional de Desenvolvimento Científico e Tecnológico (303766/2022–0); Fundação de Amparo à Pesquisa do Estado de São Paulo (2019/17947-7)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2024-06-26 · Am J Physiol Endocrinol Metab · vol. 327 · número 3 · págs. E241–E257
- Editorial
- American Physiological Society
- Citado
- 15 citas · más que el 85% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 90 trabajos
- Acceso
- De pago
- Áreas de investigación
- Gut microbiota and health · Dietary Effects on Health · Gastrointestinal motility and disorders
- Palabras clave
- intermittent fasting, alternate-day fasting, high-intensity interval training, gut microbiota, obesity, women, microbiota composition, obesity treatment
- MeSH
- feces, humans, obesity, fatty acids, volatile, fasting, adolescent, adult, female, young adult, gastrointestinal microbiome, high-intensity interval training, intermittent fasting
6 autores
- Gabriela Batitucci🇧🇷Universidade Estadual Paulista (Unesp)
- Otávio Guilherme Gonçalves de Almeida🇧🇷Universidade de São Paulo
- Elaine Cristina Pereira De Martinis🇧🇷Universidade de São Paulo
- Isabela Solar🇧🇷Universidade Estadual de Campinas (UNICAMP)
- Dennys E. Cintra🇧🇷Universidade Estadual de Campinas (UNICAMP)
- Ellen Cristini de Freitas🇧🇷Universidade de São Paulo; Universidade Estadual Paulista (Unesp)
Resumen
El texto original del estudio, en el idioma en que se publicó.
Obesity is advancing at an accelerated pace, and yet its treatment is still an emerging field. Although studies have demonstrated the role of the microbiota in the pathogenesis of obesity, this is the first study to show the effects of intermittent fasting (IF), combined or not with exercise, and high-intensity interval training (HIIT) on the gut microbiota composition in women with obesity. Our hypothesis is that IF combined with HIIT can promote the remodeling of the composition and function of the gut microbiota. Thirty-six women with obesity, aged between 18 and 40 yr, participated in the study. They were randomly divided into three groups: 1) IF associated with HIIT group [IF + exercise group (EX), n = 15]; 2) HIIT group (EX, n = 11); and 3) IF group (IF, n = 10). Interventions took place over 8 wk, and all assessments were performed preintervention and postintervention. The HIIT circuit was performed 3 times/wk, for 25 min/session. The IF protocol was a 5:2 (2 times/wk). Multiplex analysis of inflammatory cytokines, sequencing of the 16S rRNA gene, and gas chromatography to measure fecal concentrations of short-chain fatty acids (SCFAs) were performed. This study was registered on ClinicalTrials.gov (NCT05237154). Exercise increased fecal acetate concentrations (P = 0.04), but no changes were observed in the composition and functional profile of the microbiota. The interventions did not change the composition of the microbiota, but exercise may play a modulatory role in the production of acetate. This investigation provides clinical insights into the use of IF and HIIT for women with obesity.NEW & NOTEWORTHY This is the first investigation about alternate-day fasting combined with HITT on the gut microbiota of obese women. The study contributes to the advancement of human science involving IF and HIIT, popular strategies for managing obesity. Previous evidence has explored IF in modulating the microbiota in animal models or specific populations and clinical conditions. Despite the subtle outcomes, this study has relevance and originality in the field of gut microbiota knowledge.
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