Financiado en parte por Specnova, Inc. (Boca Raton, FL, USA), Increnovo LLC, Specnova LLC
Acute and Repeated Ashwagandha Supplementation Improves Markers of Cognitive Function and Mood
Leonard M, Dickerson B, Estes L, Gonzalez DE, Jenkins V, Johnson S, Xing D, Yoo C, Ko J, Purpura M, Jäger R, Faries M, Kephart W, Sowinski R, Rasmussen CJ, Kreider RB
Nutrients · 19 citas
Etiquetas de revisión
Vínculos de autores con la industriaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Specnova, Inc. (Boca Raton, FL, USA)
- Empresa
- Increnovo LLC
- Empresa
- Specnova LLC
- Autores
- Al menos un autor declara un vínculo económico con la industria
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-06-08 · Nutrients · vol. 16 · número 12 · pág. 1813
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 43 citas · más que el 100% de estudios similares · 21.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 75 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Medicinal Plants and Neuroprotection · Health, Education, and Aging
- Palabras clave
- Stroop effect, Mood, Vigilance (psychology), Medicine, Cognition, Audiology, Placebo, Profile of mood states, Effects of sleep deprivation on cognitive performance, Recall, Psychology, Clinical psychology, Psychiatry
- MeSH
- humans, plant leaves, plant roots, plant extracts, liposomes, double-blind method, affect, cognition, reaction time, dietary supplements, adolescent, adult, female, male, young adult, biomarkers
16 autores
- Megan Leonard🇺🇸Texas A&M University
- Broderick L. Dickerson🇺🇸Texas A&M University
- Landry Estes🇺🇸Texas A&M University
- Drew Edward Gonzalez🇺🇸Texas A&M University
- Victoria M. Jenkins🇺🇸Texas A&M University
- Sarah E. Johnson🇺🇸Texas A&M University
- Dante Xing🇺🇸Texas A&M University
- Choongsung Yoo🇺🇸Texas A&M University
- Joungbo Ko🇺🇸Texas A&M University
- Martin Purpura🇺🇸Increnovo LLC (United States)
- Ralf Jäger🇺🇸Increnovo LLC (United States)
- Mark B. Faries🇺🇸Texas A&M University
- Wesley C. Kephart🇺🇸University of Wisconsin–Whitewater
- Ryan J. Sowinski🇺🇸Texas A&M University
- Christopher J. Rasmussen🇺🇸Texas A&M University
- Richard B. Kreider🇺🇸 · autor de correspondenciaTexas A&M University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Ashwagandha has been reported to reduce stress and attenuate cognitive decline associated with inflammation and neurodegeneration in clinical populations. However, the effects as a potential nootropic nutrient in younger populations are unclear. This study examined the effects of liposomal ashwagandha supplementation on cognitive function, mood, and markers of health and safety in healthy young men and women.
Methods
59 men and women (22.7 ± 7 yrs., 74.9 ± 16 kg, 26.2 ± 5 BMI) fasted for 12 h, donated a fasting blood sample, and were administered the COMPASS cognitive function test battery (Word Recall, Word recognition, Choice Reaction Time Task, Picture Recognition, Digit Vigilance Task, Corsi Block test, Stroop test) and profile of mood states (POMS). In a randomized and double-blind manner, participants were administered 225 mg of a placebo (Gum Arabic) or ashwagandha (Withania somnifera) root and leaf extract coated with a liposomal covering. After 60-min, participants repeated cognitive assessments. Participants continued supplementation (225 mg/d) for 30 days and then returned to the lab to repeat the experiment. Data were analyzed using a general linear model (GLM) univariate analysis with repeated measures and pairwise comparisons of mean changes from baseline with 95% confidence intervals (CI).
Results
Ashwagandha supplementation improved acute and/or 30-day measures of Word Recall (correct and recalled attempts), Choice Reaction Time (targets identified), Picture Recognition ("yes" correct responses, correct and overall reaction time), Digit Vigilance (correct reaction time), Stroop Color-Word (congruent words identified, reaction time), and POMS (tension and fatigue) from baseline more consistently with several differences observed between groups.
Conclusion
Results support contentions that ashwagandha supplementation (225 mg) may improve some measures of memory, attention, vigilance, attention, and executive function while decreasing perceptions of tension and fatigue in younger healthy individuals. Retrospectively registered clinical trial ISRCTN58680760.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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