Effects of intermittent fasting combined with exercise on serum leptin and adiponectin in adults with or without obesity: a systematic review and meta-analysis of randomized clinical trials
Kazeminasab F, Behzadnejad N, Cerqueira HS, Santos HO, Rosenkranz SK
Frontiers in nutrition · 10 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-06-12 · Front Nutr · vol. 11 · pág. 1362731
- Editorial
- Frontiers Media
- Citado
- 13 citas · más que el 72% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 61 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Adipokines, Inflammation, and Metabolic Diseases · Regulation of Appetite and Obesity
- Palabras clave
- intermittent fasting, exercise training, leptin, adiponectin, obesity, weight loss, adipokines, combined diet and exercise intervention
5 autores
- Fatemeh Kazeminasab🇮🇷University of Kashan
- Nasim Behzadnejad🇮🇷University of Isfahan
- Henrique Santa Capita Cerqueira🇧🇷Universidade de São Paulo
- Heitor Oliveira Santos
- Sara K. Rosenkranz🇺🇸 · autor de correspondenciaUniversity of Nevada, Las Vegas
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Intermittent fasting (IF) and exercise training (Exe) have been evaluated in several studies for improving cardiometabolic biomarkers related to weight loss. However, further investigation is required to understand the potential effects on leptin and adiponectin concentrations. IF protocols have been shown to be efficient in improving adipokines, but further research is required to determine whether or not IF regimens combined with Exe are superior to Exe alone.
Objective
The aim of this study was to determine whether or not interventions combining IF plus Exe are more effective than Exe only for improving serum leptin and adiponectin in adults with and without obesity.
Data extraction
A systematic review and meta-analysis was performed by searching PubMed, Scopus, and Web of Science databases up to August 2023 for randomized clinical trials that determined the effects of IF plus Exe vs. Exe alone (control) on body weight, serum leptin, and serum adiponectin. Analyses were conducted for IF plus Exe vs. Exe alone to calculate weighted mean differences (WMD) and standardized mean differences (SMD).
Analysis
The current meta-analysis included 6 studies with a total sample of 153 participants, with intervention durations ranging from three days to 52 weeks. IF plus Exe elicited significantly larger decreases in leptin levels [SMD = -0.47, p = 0.03], which were accompanied by weight loss [WMD = -1.25 kg, p = 0.05], as compared with exercise-only interventions, but adiponectin did not differ between the two [SMD = 0.02, p = 0.9].
Conclusion
IF combined with Exe reduced leptin significantly, but did not change adiponectin levels, when compared to exercise only. Perhaps these reductions in leptin levels may have been associated with weight loss; however, due to the small number of included studies and the high heterogeneity in the weight loss outcomes, this result is uncertain.
Systematic review registration
https://www.crd.york.ac.uk/prospero/, identifier CRD42023460735.
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