The effect of live music therapy on white matter microstructure in very preterm infants - A randomized controlled trial
Dewan MV, Jungilligens J, Kobus S, Diezel M, Dathe AK, Schweiger B, Hüning B, Felderhoff-Müser U, Bruns N
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 3 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Medizinische Fakultät, Universität Duisburg-Essen
- Universidad u hospital
- Universität Duisburg-Essen Medizinische Fakultät
Según 2 financiadores declarados.
Publicación
- Publicado
- 2024-06-22 · Eur J Paediatr Neurol · vol. 51 · págs. 132–139
- Editorial
- Elsevier BV
- Citado
- 4 citas · más que el 85% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 66 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Music Therapy and Health · Infant Development and Preterm Care · Neonatal and fetal brain pathology
- Palabras clave
- music therapy, very preterm infants, white matter microstructure, fractional anisotropy, neonatal intensive care, brain development, superior longitudinal fasciculus, corpus callosum, corticospinal tract, external capsule, forceps minor
- MeSH
- humans, music therapy, infant, newborn, infant, premature, female, male, diffusion tensor imaging, infant, extremely premature, white matter
9 autores
- Monia Vanessa Dewan🇩🇪 · autor de correspondenciaEssen University Hospital; University of Duisburg-Essen
- Johannes Jungilligens🇩🇪Universitätsklinikum Knappschaftskrankenhaus Bochum; Ruhr University Bochum
- Susann Kobus🇩🇪Essen University Hospital; University of Duisburg-Essen
- Marlis Diezel🇩🇪Essen University Hospital; University of Duisburg-Essen
- Anne-Kathrin Dathe🇩🇪Ernst Abbe University of Applied Sciences Jena; Essen University Hospital; University of Duisburg-Essen
- Bernd Schweiger🇩🇪Essen University Hospital; University of Duisburg-Essen
- Britta Maria Hüning🇩🇪Essen University Hospital; University of Duisburg-Essen
- Ursula Felderhoff‐Müser🇩🇪Essen University Hospital; University of Duisburg-Essen
- Nora Bruns🇩🇪Essen University Hospital; University of Duisburg-Essen
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Music therapy (MT) is proposed to enrich the acoustic environment of very preterm infants (VPT) on the neonatal intensive care unit during a vulnerable period of brain development. The objective of this study was to investigate the effect of MT on the white matter (WM) microstructure. It is hypothesized that MT affects WM integrity in VPT.
Methods
Randomized controlled trial enrolling infants born <32 weeks' gestation. Infants were randomized to MT or standard care. Live MT was provided twice weekly from the second postnatal week onwards by a trained music therapist. At term equivalent age, participants underwent a cranial magnetic resonance imaging scan including sequences for diffusion tensor imaging analysis. Differences in WM microstructure were assessed using tract based spatial statistics with fractional anisotropy.
Results
Of 80 infants enrolled, 42 were eligible for diffusion tensor imaging analysis (MT: n = 22, standard care: n = 20). While primary tract based spatial statistics analysis revealed no significant differences between groups, post hoc analysis with uncorrected p-values and a significance threshold of p < 0.01 revealed significant fractional anisotropy differences in several WM tracts including the bilateral superior longitudinal fasciculus, the left forceps minor and left fasciculus uncinatus, the corpus callosum, the left external capsule, and the right corticospinal tract.
Conclusion
Post hoc analysis results suggest an effect of MT on WM integrity in VPT. Larger studies including long-term outcome are necessary to confirm these effects of MT on WM microstructure and to assess its impact on clinical neurodevelopment.
Clinical trial registration
Clinical trial number DRKS00025753.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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