The effects of intermittent fasting on body composition and cardiometabolic health in adults with prediabetes or type 2 diabetes: A systematic review and meta-analysis
Khalafi M, Habibi Maleki A, Symonds ME, Rosenkranz SK, Rohani H, Ehsanifar M
Diabetes, obesity & metabolism · 26 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2024-07-02 · Diabetes Obes Metab · vol. 26 · número 9 · págs. 3830–3841
- Editorial
- Wiley
- Citado
- 38 citas · más que el 93% de estudios similares · 2.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 79 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Diabetes, Cardiovascular Risks, and Lipoproteins · Diet and metabolism studies
- Palabras clave
- intermittent fasting, prediabetes, type 2 diabetes, body composition, cardiometabolic health, caloric restriction, weight loss, HbA1c, fasting blood glucose, lipid profile, blood pressure, insulin
- MeSH
- humans, cardiovascular diseases, diabetes mellitus, type 2, prediabetic state, blood glucose, caloric restriction, fasting, body composition, adult, randomized controlled trials as topic, intermittent fasting
6 autores
- Mousa Khalafi🇮🇷 · autor de correspondenciaUniversity of Kashan
- Aref Habibi Maleki🇮🇷 · autor de correspondenciaUrmia University
- Michael Edward Symonds🇬🇧University of Nottingham
- Sara K. Rosenkranz🇺🇸University of Nevada, Las Vegas
- Hadi Rohani🇮🇷Sport Sciences Research Institute
- Mahsa Ehsanifar🇮🇷Urmia University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aim
To perform a meta-analysis to investigate the effects of intermittent fasting (IF), as compared with either a control diet (CON) and/or calorie restriction (CR), on body composition and cardiometabolic health in individuals with prediabetes and type 2 diabetes (T2D).
Methods
PubMed, Web of Science, and Scopus were searched from their inception to March 2024 to identify original randomized trials with parallel or crossover designs that studied the effects of IF on body composition and cardiometabolic health. Weighted mean differences (WMDs) or standardized mean differences with 95% confidence intervals (CIs) were calculated using random-effects models.
Results
Overall, 14 studies involving 1101 adults with prediabetes or T2D were included in the meta-analysis. IF decreased body weight (WMD -4.56 kg [95% CI -6.23 to -2.83]; p = 0.001), body mass index (BMI; WMD -1.99 kg.m2 [95% CI -2.74 to -1.23]; p = 0.001), glycated haemoglobin (HbA1c; WMD -0.81% [95% CI -1.24 to -0.38]; p = 0.001), fasting glucose (WMD -0.36 mmol/L [95% CI -0.63 to -0.09]; p = 0.008), total cholesterol (WMD -0.31 mmol/L [95% CI -0.60 to -0.02]; p = 0.03) and triglycerides (WMD -0.14 mmol/L [95% CI -0.27 to -0.01]; p = 0.02), but did not significantly decrease fat mass, insulin, low-densitiy lipoprotein, high-density lipoprotein, or blood pressure as compared with CON. Furthermore, IF decreased body weight (WMD -1.14 kg [95% CI -1.69 to -0.60]; p = 0.001) and BMI (WMD -0.43 kg.m2 [95% CI -0.58 to -0.27]; p = 0.001), but did not significantly affect fat mass, lean body mass, visceral fat, insulin, HbA1c, lipid profiles or blood pressure.
Conclusion
Intermittent fasting is effective for weight loss and specific cardiometabolic health markers in individuals with prediabetes or T2D. Additionally, IF is associated with a reduction in body weight and BMI compared to CR, without effects on glycaemic markers, lipid profiles or blood pressure.
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