Efficacy of Magnesium Supplementation in Cancer Patients Developing Hypomagnesemia Due to Anti-EGFR Antibody: A Systematic Review
Kato T, Kawaguchi T, Funakoshi T, Fujiwara Y, Yasuda Y, Ando Y
Cancer diagnosis & prognosis · 4 citas
Cómo se estudió
- Diseño
- Revisión sistemática (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Nara Medical University
- Universidad u hospital
- Kawasaki Medical School
Según 2 financiadores declarados.
Publicación
- Publicado
- 2024-07-01 · Cancer Diagn Progn · vol. 4 · número 4 · págs. 390–395
- Citado
- 4 citas · más que el 50% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 23 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Magnesium in Health and Disease · Potassium and Related Disorders · Parathyroid Disorders and Treatments
- Palabras clave
- Hypomagnesemia, Medicine, Cetuximab, Internal medicine, Antibody, Cochrane Library, Cancer, Meta-analysis, Gastroenterology, Colorectal cancer, Magnesium, Immunology, Chemistry
6 autores
- Taigo Kato🇯🇵The University of Osaka
- Takahisa Kawaguchi🇯🇵Kawasaki Municipal Hospital
- Taro Funakoshi🇯🇵Kyoto University
- Yutaka Fujiwara🇯🇵Aichi Cancer Center
- Yoshinari Yasuda🇯🇵Nagoya University
- Yuichi Ando🇯🇵Nagoya University Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/aim
Hypomagnesemia is a common side effect of anti-epidermal growth factor receptor (EGFR) antibodies, which may lead to arrhythmia. However, there are no evidence-based guidelines for magnesium (Mg) supplementation in the management of hypomagnesemia in patients with anti-EGFR antibodies. Therefore, we performed a systematic review to address clinical questions regarding these cancer patients.
Materials and methods
Three electronic databases were searched for articles published until June 18, 2021. The main outcomes used were "anti-EGFR antibody" and "hypomagnesemia".
Results
After screening 78 references in PubMed, Cochrane Library, and ICHUSHI-web databases, three studies were included in the review. One study revealed the effectiveness of Mg supplementation in the management of hypomagnesemia in patients receiving cetuximab. However, no studies have investigated whether correcting hypomagnesemia can lead to the suppression of arrhythmias as a clinical outcome.
Conclusion
Weak evidence suggests that Mg supplementation, as a preventive measure when developing hypomagnesemia following the initiation of anti-EGFR antibody therapy, may prevent the worsening of hypomagnesemia, and subsequently prevent associated arrhythmia occurrence.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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