Effects of Ashwagandha ( <i>Withania somnifera</i>) standardized root extract on physical endurance and VO <sub>2max</sub> in healthy adults performing resistance training: An eight-week, prospective, randomized, double-blind, placebo-controlled study
Verma N, Gupta SK, Patil S, Tiwari S, Mishra AK
F1000Research · 15 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-04-08 · F1000Res · vol. 12 · pág. 335
- Editorial
- Faculty of 1000
- Citado
- 19 citas · más que el 98% de estudios similares · 9.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Pharmacology and Nanomedicine Research · Mindfulness and Compassion Interventions
- Palabras clave
- Withania somnifera, Medicine, Open peer review, Placebo, Resistance training, Physical therapy, Endurance training, Physiology, Plant biology, Double blind, Traditional medicine, Physical medicine and rehabilitation, Biology, Alternative medicine, Botany
- MeSH
- humans, withania, plant roots, plant extracts, prospective studies, double-blind method, oxygen consumption, physical endurance, adolescent, adult, middle aged, female, male, muscle strength, resistance training, young adult
5 autores
- Narsingh Verma🇮🇳King George's Medical University
- Sandeep Kumar Gupta🇮🇳M.V. Hospital and Research Centre
- Sayali Patil🇮🇳 · autor de correspondenciaD.Y. Patil University
- Shashank Tiwari🇮🇳King George's Medical University
- Ashok Kumar Mishra🇮🇳M.V. Hospital and Research Centre
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Ashwagandha is a well-known Ayurvedic herb used for youthful vigor and wellbeing. This study investigated the effects of 600 mg standardized root extract (>5% withanolides) of Ashwagandha ( Withania somnifera) on muscle size, strength and cardiorespiratory endurance following resistance training.
Methods
In this eight-week, parallel-group, multicenter, randomized, double-blind, placebo-controlled clinical study, 80 healthy male and female participants aged 18-45 years, who engaged in regular physical activity were randomly allocated in a 1:1 ratio to receive Ashwagandha (AG, n=40) 300 mg capsules twice daily for eight weeks, or identical placebo (PB, n=40). Seven (3 AG, 4 PB) participants were excluded due to poor compliance. All participants conducted eight-week resistance training. Study outcomes included muscle strength (1RM bench press and leg extension), muscle size (circumference of arm, chest and upper thigh) and cardio-respiratory endurance (VO 2max) assessed at baseline and at eight weeks. Analysis of covariance (ANCOVA) was used to estimate adjusted differences based on sex, BMI and chest circumference at baseline.
Results
AG caused greater improvement in bench press (males: p = 0.0084; females: p = 0.0005), leg press (males: p = 0.0049; females: p = 0.018) and endurance (males: p <0.0001; females: p <0.0001) as compared to PB. Also, greater improvements in muscle girth for arm, chest and thigh were seen in both male and female participants with AG. No adverse events were reported in the study.
Conclusions
Eight weeks of AG root extract supplementation along with resistance training is effective in improving muscle strength, growth and endurance in both male and female participants. AG root extract could be a safer, effective and low-cost alternative for athletes to improve muscle endurance.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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