Intermittent Fasting Attenuates Obesity-Induced Triple-Negative Breast Cancer Progression by Disrupting Cell Cycle, Epithelial-Mesenchymal Transition, Immune Contexture, and Proinflammatory Signature
Son DS, Done KA, Son J, Izban MG, Virgous C, Lee ES, Adunyah SE
Nutrients · 12 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Environmental Health Sciences
- Gobierno
- National Institute on Minority Health and Health Disparities
- Gobierno
- National Institutes of Health (NIH)
- Gobierno
- NIEHS NIH HHS
- Gobierno
- NCI NIH HHS
- Gobierno
- NIH HHS
- Organización sin fines de lucro
- ACS
- Gobierno
- NIMHD NIH HHS
- Subvenciones
- National Cancer Institute (U54 CA-163069); National Cancer Institute (SC1CA200519); National Institutes of Health (ACS DICRIDG-21-071-01-DICRIDG); National Cancer Institute (P50 CA098131); National Institute on Minority Health and Health Disparities (U54MD007586); National Institutes of Health (U54CA163069); National Institutes of Health (NCI P50 CA098131); National Institutes of Health (1P50CA098131-21A1); National Institutes of Health (NCI SC1CA200519); National Institutes of Health (1U54CA163069-21A1); National Institute of Environmental Health Sciences (R01ES031282)
Según 10 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-07-01 · Nutrients · vol. 16 · número 13 · pág. 2101
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 14 citas · más que el 93% de estudios similares · 3.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 97 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Cancer, Lipids, and Metabolism · Cancer Risks and Factors
- Palabras clave
- intermittent fasting, triple-negative breast cancer, obesity, fasting-mimicking diet, cell cycle, epithelial-mesenchymal transition, tumor microenvironment, macrophage accumulation, cyclin B1, vimentin, tumor progression, adjuvant therapy, lifestyle intervention
- MeSH
- cell line, tumor, animals, humans, mice, mice, obese, obesity, disease progression, inflammation, fasting, cell cycle, cell proliferation, cell movement, female, epithelial-mesenchymal transition, tumor microenvironment, triple negative breast neoplasms, intermittent fasting
7 autores
- Deok‐Soo Son🇺🇸 · autor de correspondenciaMeharry Medical College
- Kaitlyn A. Done🇺🇸Spelman College
- Jubin Son🇺🇸University of Tennessee at Knoxville
- Michael G. Izban🇺🇸Meharry Medical College
- Carlos K Virgous🇺🇸Meharry Medical College
- Eun-Sook Lee🇺🇸Florida Agricultural and Mechanical University
- Samuel Evans Adunyah🇺🇸Meharry Medical College
Resumen
El texto original del estudio, en el idioma en que se publicó.
Obesity is associated with one-fifth of cancer deaths, and breast cancer is one of the obesity-related cancers. Triple-negative breast cancer (TNBC) lacks estrogen and progesterone receptors and human epidermal growth factor receptor 2, leading to the absence of these therapeutic targets, followed by poor overall survival. We investigated if obesity could hasten TNBC progression and intermittent fasting (IF) could attenuate the progression of obesity-related TNBC. Our meta-analysis of the TNBC outcomes literature showed that obesity led to poorer overall survival in TNBC patients. Fasting-mimicking media reduced cell proliferation disrupted the cell cycle, and decreased cell migration and invasion. IF decreased body weight in obese mice but no change in normal mice. Obese mice exhibited elevated plasma glucose and cholesterol levels, increased tumor volume and weight, and enhanced macrophage accumulation in tumors. The obesity-exacerbated TNBC progression was attenuated after IF, which decreased cyclin B1 and vimentin levels and reduced the proinflammatory signature in the obesity-associated tumor microenvironment. IF attenuated obesity-induced TNBC progression through reduced obesity and tumor burdens in cell and animal experiments, supporting the potential of a cost-effective adjuvant IF therapy for TNBC through lifestyle change. Further evidence is needed of these IF benefits in TNBC, including from human clinical trials.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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