Creatine supplementation protocols with or without training interventions on body composition: a GRADE-assessed systematic review and dose-response meta-analysis
Pashayee-Khamene F, Heidari Z, Asbaghi O, Ashtary-Larky D, Goudarzi K, Forbes SC, Candow DG, Bagheri R, Ghanavati M, Dutheil F
Journal of the International Society of Sports Nutrition · 18 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Shahid Beheshti University of Medical Sciences
- Universidad u hospital
- National Nutrition and Food Technology Research Institute
- Autores
- Al menos un autor declara un vínculo económico con la industria
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-07-23 · J Int Soc Sports Nutr · vol. 21 · número 1 · pág. 2380058
- Editorial
- Springer Science+Business Media
- Citado
- 27 citas · más que el 84% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 183 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Muscle metabolism and nutrition · Sports Performance and Training · Biochemical effects in animals
- Palabras clave
- creatine supplementation, body composition, resistance training, fat-free mass, body fat percentage, maintenance dose, dose-response relationship
- MeSH
- humans, creatine, body composition, dose-response relationship, drug, dietary supplements, randomized controlled trials as topic, resistance training
10 autores
- Fereshteh Pashayee-Khamene🇮🇷Ahvaz Jundishapur University of Medical Sciences
- Zeinab Heidari🇮🇷Ahvaz Jundishapur University of Medical Sciences
- Omid Asbaghi🇮🇷Shahid Beheshti University of Medical Sciences
- Damoon Ashtary‐Larky🇮🇷Ahvaz Jundishapur University of Medical Sciences
- Kian Goudarzi🇮🇷Shahid Beheshti University of Medical Sciences
- Scott C. Forbes🇨🇦Brandon University
- Darren Glenn Candow🇨🇦University of Regina
- Reza Bagheri🇮🇷University of Isfahan
- Matin Ghanavati🇮🇷 · autor de correspondenciaNational Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Frédéric Dutheil🇫🇷Centre National de la Recherche Scientifique; Université Clermont Auvergne; Laboratoire de Psychologie Sociale et Cognitive
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Despite the robust evidence demonstrating positive effects from creatine supplementation (primarily when associated with resistance training) on measures of body composition, there is a lack of a comprehensive evaluation regarding the influence of creatine protocol parameters (including dose and form) on body mass and estimates of fat-free and fat mass.
Methods
Randomized controlled trials (RCTs) evaluating the effect of creatine supplementation on body composition were included. Electronic databases, including PubMed, Web of Science, and Scopus were searched up to July 2023. Heterogeneity tests were performed. Random effect models were assessed based on the heterogeneity tests, and pooled data were examined to determine the weighted mean difference (WMD) with a 95% confidence interval (CI).
Results
From 4831 initial records, a total of 143 studies met the inclusion criteria. Creatine supplementation increased body mass (WMD: 0.86 kg; 95% CI: 0.76 to 0.96, I2 = 0%) and fat-free mass (WMD: 0.82 kg; 95% CI: 0.57 to 1.06, I2 = 0%) while reducing body fat percentage (WMD: -0.28 %; 95% CI: -0.47 to -0.09; I2 = 0%). Studies that incorporated a maintenance dose of creatine or performed resistance training in conjunction with supplementation had greater effects on body composition.
Conclusion
Creatine supplementation has a small effect on body mass and estimates of fat-free mass and body fat percentage. These findings were more robust when combined with resistance training.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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