Effects of acute creatine supplementation on cardiac and vascular responses in older men; a randomized controlled trial
Aron A, Landrum EJ, Schneider AD, Via M, Evans L, Rawson ES
Clinical nutrition ESPEN · 4 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Radford University
Según 1 financiador declarado.
Publicación
- Publicado
- 2024-07-22 · Clin Nutr ESPEN · vol. 63 · págs. 557–563
- Editorial
- Elsevier BV
- Citado
- 5 citas · más que el 70% de estudios similares · 0.9× el promedio de su campo
- Referencias
- 61 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Cardiovascular Health and Disease Prevention · Biochemical effects in animals
- Palabras clave
- creatine supplementation, acute supplementation, older men, arterial stiffness, pulse wave velocity, cardiovascular risk factors, atherosclerosis, systolic blood pressure, cardiac contractility, ejection fraction, stroke volume, cardiovascular disease prevention, vascular function, impedance cardiography, cardio-ankle vascular index, dyslipidemia, hyperglycemia, chronic inflammation
- MeSH
- heart, humans, cardiovascular diseases, creatine, double-blind method, blood pressure, dietary supplements, aged, aged, 80 and over, middle aged, male, vascular stiffness, pulse wave analysis
6 autores
- Adrian Aron🇺🇸 · autor de correspondenciaRadford University
- Erynn Landrum🇺🇸Radford University
- Adam D Schneider🇺🇸Radford University
- Megan Via🇺🇸Radford University
- Logan Evans🇺🇸Radford University
- Eric S. Rawson🇺🇸Messiah University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aims
In the recent years creatine has been shown promising results in patients with neurodegenerative diseases, myopathies and dystrophies. Cardiovascular diseases could be another pathology that can benefit from creatine supplementation, considering the influence on the risk factors associated with the development of cardiovascular diseases including reduction in chronic inflammation, and improved control of hyperglycemia and dyslipidemia The aim of the present study was to investigate the impact of short-term creatine supplementation on cardiac and vascular health in older adults.
Methods
Males between the ages of 55-80 were randomly assigned to three groups: creatine, placebo and control. Creatine or placebo was provided for 7-day supplementation, at a dose of 20 g/day. Testing was performed at the same time of the day at baseline and on the eighth day. Vascular responses were assessed using an arterial pulse wave velocity equipment, while cardiac assessment was performed using an impedance cardiography device.
Results
The placebo group was older (71.1 ± 8.2 yr) compared to creatine (61.4 ± 5.2 yr) and control (62.5 ± 7.1 yr). Cardio-ankle vascular index improved just in the creatine group (8.7 ± 0.5 to 8.2 ± 0.5, p = 0.03). While the upstroke time of the placebo and control groups did not change after 7 days, the creatine group had a nonsignificant reduction, 178.9 ± 26.5 ms to 158.4 ± 28.6 ms, p = 0.07. Similar tendency was seen with the systolic blood pressures, while the placebo and control did not change, the creatine group showed nonsignificant improvement, especially on the right, 144.0 ± 12.7 mmHg to 136.1 ± 13.4 mmHg, p = 0.08. All three groups had similar responses in stroke volume (p = 0.61), contractility index (p = 0.64) and ejection fraction (p = 0.72).
Conclusions
In older adults, acute creatine supplementation can positively affect vascular parameters of arterial stiffness and atherosclerosis. Creatine supplementation has the potential to serve as a potent adjuvant in the management of CVD for older adults.
Clinical trial registration
clinicaltrials.gov; ID: NCT05329480.
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