Safety and efficacy of Withania somnifera for anxiety and insomnia: Systematic review and meta-analysis
Fatima K, Malik J, Muskan F, Raza G, Waseem A, Shahid H, Jaffery SF, Khan U, Zaheer MK, Shaikh Y, Rashid AM
Human psychopharmacology · 11 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2024-07-31 · Hum Psychopharmacol · vol. 39 · número 6 · pág. e2911
- Editorial
- Wiley
- Citado
- 14 citas · más que el 89% de estudios similares · 2.6× el promedio de su campo
- Referencias
- 21 trabajos
- Acceso
- De pago
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Mindfulness and Compassion Interventions · Piperaceae Chemical and Biological Studies
- Palabras clave
- Insomnia, Pittsburgh Sleep Quality Index, Anxiety, Cochrane Library, Meta-analysis, Randomized controlled trial, Sleep onset, Withania somnifera, Sleep onset latency, Primary Insomnia, Medicine, Placebo, Confidence interval, Psychiatry, Physical therapy, Internal medicine, Sleep disorder, Sleep quality, Alternative medicine
- MeSH
- humans, withania, sleep initiation and maintenance disorders, plant extracts, treatment outcome, phytotherapy, anxiety, randomized controlled trials as topic
11 autores
- Kaneez Fatima🇵🇰Dow University of Health Sciences
- Javeria Malik🇵🇰 · autor de correspondenciaDow University of Health Sciences
- Fnu Muskan🇵🇰Karachi Medical and Dental College
- Ghana Raza🇵🇰Jinnah Sindh Medical University
- Areesha Waseem🇵🇰Karachi Medical and Dental College
- Hiba Shahid🇵🇰Liaquat National Hospital
- Syeda Fatima Jaffery🇵🇰Dow University of Health Sciences
- Umeed Ali Khan🇵🇰Ziauddin University
- Muhammad Kashan Zaheer🇵🇰Liaquat National Hospital
- Yasmeen Shaikh🇵🇰Dow University of Health Sciences
- Ahmed Mustafa Rashid🇵🇰Jinnah Sindh Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Despite the historical neurological use of Withania somnifera, limited evidence supports its efficacy for conditions like anxiety and insomnia. Given its known anti-stress properties, this review evaluated its safety and efficacy for anxiety and insomnia.
Methods
We searched Medline, Cochrane Library, and Google Scholar until August 2023 for randomized controlled trials (RCTs) comparing W. somnifera to placebo in patients with anxiety and/or insomnia. Outcome measures included changes in anxiety levels via the Hamilton Anxiety Scale (HAM-A), Sleep Onset Latency (SOL), Total Sleep Time (TST), Wake After Sleep Onset (WASO), Total Time in Bed (TIB), Sleep Efficiency (SE), and Pittsburgh Sleep Quality Index (PSQI) score. We utilized a random-effect model for pooling Mean Differences (MD) with a 95% Confidence Interval (CI). Heterogeneity was assessed through sensitivity and subgroup analysis, and the quality of RCTs was evaluated using the Cochrane revised risk of bias tool.
Results
Pooled results from five RCTs (n = 254) demonstrated that W. somnifera significantly reduced HAM-A scores (MD = -5.96; [95% CI -10.34, -1.59]; P = 0.008; I2 = 98%), as well as sleep parameters such as SOL, TST, PSQI, and SE, but not WASO and TIB.
Conclusion
While W. somnifera extracts yielded promising results, further research with larger sample sizes is needed to confirm its effects on anxiety and insomnia.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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