Financiado en parte por Fundación Mapfre, MAPFRE Foundation, Ignacio H. de Larramendi, MAPFRE Foundation
Association of Genetic Profile with Muscle Mass Gain and Muscle Injury Prevention in Professional Football Players after Creatine Supplementation
Varillas-Delgado D
Nutrients · 15 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Fundación Mapfre
- Empresa
- MAPFRE Foundation, Ignacio H. de Larramendi
- Empresa
- MAPFRE Foundation
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-08-01 · Nutrients · vol. 16 · número 15 · pág. 2511
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 18 citas · más que el 97% de estudios similares · 6.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 97 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Genetics and Physical Performance · Muscle metabolism and nutrition · Sports Performance and Training
- Palabras clave
- Creatine, Body mass index, Medicine, Internal medicine, Anthropometry, Endocrinology, Odds ratio, Athletes, Physical therapy
- MeSH
- muscle, skeletal, humans, athletic injuries, creatine, amp deaminase, peptidyl-dipeptidase a, actinin, body mass index, longitudinal studies, genotype, polymorphism, single nucleotide, soccer, dietary supplements, adult, male, creatine kinase, mm form, young adult, athletes
1 autor
- David Varillas‐Delgado🇪🇸 · autor de correspondenciaUniversidad Francisco de Vitoria
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
In recent years, the study of creatine supplementation in professional athletes has been of great interest. However, the genetics involved in response to supplementation is unknown. The aim of this study was to analyse, for the first time, the relationship between muscle performance-related genes and the risk of an increased body mass index (BMI) and muscle mass and a decrease in fat mass in professional football players after creatine supplementation.
Methods
For this longitudinal study, one hundred and sixty-one men's professional football players were recruited. The polymorphisms ACE I/D, ACTN3 c.1729C>T, AMPD1 c.34C>T, CKM c.*800A>G, and MLCK (c.49C>T and c.37885C>A) were genotyped using Single-Nucleotide Primer Extension (SNPE). To assess the combined impact of these six polymorphisms, a total genotype score (TGS) was calculated. The creatine supplementation protocol consisted of 20 g/day of creatine monohydrate for 5 days (loading dose) and 3-5 g/day for 7 weeks (maintenance dose). Anthropometric characteristics (body mass index (BMI), fat, and muscle mass) were recorded before and after the creatine supplementation protocol. Characteristics of non-contact muscle injuries during the 2022/2023 season were classified according to a consensus statement for injury recording. The results showed that the allelic frequencies of ACE and AMPD1 differed between responders and non-responders in muscle mass increase (all p p = 0.001) for muscle mass increase. By contrast, those with a TGS below 54.16 a.u. had an OR of 9.385 (95%CI: 4.535-19.425; p < 0.001) for suffering non-contact muscle injuries during the season.
Conclusions
The increase in BMI and muscle mass in response to creatine supplementation in professional football players was influenced by a TGS derived from the combination of favourable genotypes linked to muscle performance. The CC genotype and C allele of AMPD1 were particularly associated with a higher likelihood of muscle mass increase under creatine supplementation in this group of professional football players.
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