The effects of time-restricted eating alone or in combination with probiotic supplementation in comparison with a calorie-restricted diet on endocrine and metabolic profiles in women with polycystic ovary syndrome: A randomized clinical trial
Talebi S, Shab-Bidar S, Moini A, Mohammadi H, Djafarian K
Diabetes, obesity & metabolism · 12 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Tehran University of Medical Sciences and Health Services
- Universidad u hospital
- School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS)
- Subvenciones
- Tehran University of Medical Sciences and Health Services (1401-3-212-62416)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2024-08-14 · Diabetes Obes Metab · vol. 26 · número 10 · págs. 4468–4479
- Editorial
- Wiley
- Citado
- 31 citas · más que el 99% de estudios similares · 10.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 55 trabajos
- Acceso
- De pago
- Áreas de investigación
- Ovarian function and disorders · Dietary Effects on Health · Eating Disorders and Behaviors
- Palabras clave
- polycystic ovary syndrome, time-restricted eating, intermittent fasting, probiotic supplementation, calorie-restricted diet, weight loss, body mass index, hirsutism, acne, menstrual cycle, gonadal hormones, cardiometabolic risk, women
- MeSH
- humans, polycystic ovary syndrome, obesity, weight loss, combined modality therapy, caloric restriction, diet, reducing, fasting, dietary supplements, probiotics, adult, female, young adult
5 autores
- Sepide Talebi🇮🇷Tehran University of Medical Sciences
- Sakineh Shab‐Bidar🇮🇷Tehran University of Medical Sciences
- Ashraf Moini🇮🇷Royan Institute; Academic Center for Education, Culture and Research; Tehran University of Medical Sciences
- Hamed Mohammadi🇮🇷Tehran University of Medical Sciences
- Kurosh Djafarian🇮🇷 · autor de correspondenciaTehran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aim
To assess the impact of intermittent fasting, with or without probiotic supplementation, versus a calorie-restricted diet on anthropometric measures, metabolic status and gonadal variables in women with polycystic ovary syndrome (PCOS).
Methods
This is a randomized, placebo-controlled, parallel-arm clinical trial. The effects of the 14:10 early time-restricted eating (eTRE) strategy alone or combined with probiotics, on obese women with PCOS, were investigated. Participants were divided into three groups: eTRE plus probiotics (n = 30), eTRE plus placebo (n = 30) and a control group following a standard three-meal-per-day diet with daily calorie restriction (DCR) (n = 30). Over 8 weeks, various anthropometric, metabolic, menstrual and gonadal variables were assessed.
Results
A total of 90 individuals were included in the study, with a mean body weight of 81.4 kg, and a mean age of 30 years. Mean (standard deviation) weight loss was not different between the groups at week 8 (TRE + probiotic: -2.2 [1.6] kg vs. TRE + placebo: -2.9 [2.7] kg vs. DCR: -2.5 [1.7] kg). Results revealed that, while all three regimes led to reductions in body weight, body mass index, vascular risk indicators, hirsutism and acne scores, there were no statistically significant differences between the eTRE groups and the control group in terms of weight loss, or improvements in metabolic, menstrual and gonadal variables (P > .05). Additionally, combining probiotics with eTRE did not benefit hormonal and cardiometabolic factors (P > .05).
Conclusions
The eTRE alone or eTRE plus probiotics did not result in significantly greater weight loss or improvements in metabolic, menstrual and gonadal variables compared with the standard three-meal DCR diet.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.