Effectiveness of Enriched Milk with Ashwagandha Extract and Tryptophan for Improving Subjective Sleep Quality in Adults with Sleep Problems: A Randomized Double-Blind Controlled Trial
Pérez-Piñero S, Muñoz-Carrillo JC, Echepare-Taberna J, Muñoz-Cámara M, Herrera-Fernández C, Ávila-Gandía V, Heres Fernández Ladreda M, Menéndez Martínez J, López-Román FJ
Clocks & sleep · 4 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-08-09 · Clocks Sleep · vol. 6 · número 3 · págs. 417–432
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 6 citas · más que el 86% de estudios similares · 2.0× el promedio de su campo
- Referencias
- 52 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Sleep and related disorders · Medicinal Plant Extracts Effects · Mindfulness and Compassion Interventions
- Palabras clave
- Withania somnifera, Insomnia, Medicine, Randomized controlled trial, Anxiety, Physical therapy, Internal medicine, Pharmacology, Psychiatry
9 autores
- Silvia Pérez-Piñero🇪🇸Universidad Católica de Murcia
- Juan Carlos Muñoz-Carrillo🇪🇸Universidad Católica de Murcia
- Jon Echepare-Taberna🇪🇸Universidad Católica de Murcia
- Macarena Muñoz-Cámara🇪🇸Universidad Católica de Murcia
- Cristina Herrera-Fernández🇪🇸Universidad Católica de Murcia
- Vicente Ávila-Gandía🇪🇸Universidad Católica de Murcia
- María Heres Fernández Ladreda🇪🇸Consorci d’Atenció Primària de Salut Barcelona Esquerra
- Javier Menéndez Martínez🇪🇸Consorci d’Atenció Primària de Salut Barcelona Esquerra
- Francisco Javier López-Román🇪🇸 · autor de correspondenciaInstituto Murciano de Investigación Biosanitaria; Universidad Católica de Murcia
Resumen
El texto original del estudio, en el idioma en que se publicó.
A randomized, double-blind and controlled study was conducted to assess the effectiveness of the intake of 250 mL of lactose-free skimmed milk enriched with ashwagandha (Withania somnifera) alone or combined with tryptophan vs. non-enriched milk (control) on the subjective quality of sleep in healthy adults with sleep problems. The duration of supplementation was 90 days. Fifty-two eligible subjects were assigned to the study arms of ashwagandha 250 mg, ashwagandha 250 mg plus tryptophan 175 mg, ashwagandha 600 mg, and control with 13 subjects in each group. It was hypothesized that ashwagandha plus tryptophan could be superior to ashwagandha alone for improving sleep-related variables. Changes in the visual analogue scale (VAS) for sleep quality were significantly higher in the three experimental groups as compared with controls (p = 0.014). Improvements in the subscales of the Pittsburg Sleep Quality Index (PSQI) were found in all groups, but between-group differences were not significant. In the index of insomnia severity, decreases were higher in the three experimental groups as compared with controls especially in the group of ashwagandha 600 mg. Daytime somnolence was also reduced in the three experimental groups. Changes in anxiety levels and Morningness-Eveningness Questionnaire were not observed. The study products did not elicit changes in body composition and were well tolerated and safe. The data did not support the hypothesis, as the combination of ashwagandha and tryptophan did not show greater benefits in improving sleep quality than ashwagandha alone. However, the results from the three experimental groups containing ashwagandha were more favorable compared to the placebo group.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.