Effect of Time-Restricted Eating on β-Cell Function in Adults With Type 2 Diabetes
Kramer CK, Zinman B, Feig DS, Retnakaran R
The Journal of clinical endocrinology and metabolism · 11 citas
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Cómo se estudió
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- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
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Quién lo pagó
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- Financiación no declarada
Publicación
- Publicado
- 2024-08-26 · J Clin Endocrinol Metab · vol. 110 · número 6 · págs. e2045–e2053
- Editorial
- Oxford University Press
- Citado
- 21 citas · más que el 96% de estudios similares · 4.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 34 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Circadian rhythm and melatonin · Enhanced Recovery After Surgery
- Palabras clave
- Type 2 diabetes, Randomized controlled trial, BETA (programming language), Diabetes mellitus, Medicine, Internal medicine, Psychology, Endocrinology, Computer science
- MeSH
- humans, diabetes mellitus, type 2, insulin resistance, blood glucose, glucose tolerance test, body mass index, fasting, cross-over studies, time factors, adult, aged, middle aged, female, male, overweight, insulin-secreting cells, glycated hemoglobin
4 autores
- Caroline Kaercher Kramer🇨🇦🇺🇸 · autor de correspondenciaMount Sinai Hospital; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital
- Bernard Zinman🇨🇦🇺🇸Mount Sinai Hospital; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital
- Denice S. Feig🇨🇦🇺🇸Mount Sinai Hospital; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital
- Ravi R. Retnakaran🇨🇦🇺🇸Mount Sinai Hospital; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Time-restricted eating (TRE), which consists of restricting the eating window to typically 4 to 8 hours (while fasting for the remaining hours of the day), has been proposed as a nonpharmacological strategy with cardiometabolic benefits but little is known about its metabolic effect on type 2 diabetes mellitus (T2DM).
Objective
We evaluated whether TRE can improve pancreatic β-cell function and metabolic status in overweight individuals with early T2DM.
Methods
In a randomized, crossover trial, 39 participants (mean 2.9 years of diabetes duration, baseline glycated hemoglobin A1c [HbA1c] 6.6% ± 0.7% and body mass index [BMI] 32.4 ± 5.7) were randomly assigned to either an initial intervention consisting of 6 weeks of TRE (20 h-fasting/4 h-eating) or standard lifestyle. The primary outcome of β-cell function was assessed by the Insulin Secretion-Sensitivity Index-2 (ISSI-2) derived from an oral glucose tolerance test.
Results
As compared to standard lifestyle, TRE induced a 14% increase in ISSI-2 (+14.0 ± 39.2%; P = .03) accompanied by a 14% reduction of hepatic insulin resistance as evaluated by HOMA-IR (-11.6% [-49.3 to 21.9]; P = .03). Fasting glucose did not differ between interventions, but TRE yielded a statistically significant reduction in HbA1c (-0.32 ± 0.48%; P < .001). These metabolic improvements were coupled with a reduction of body weight of 3.86% (-3.86 ± 3.1%; P < .001) and waist circumference of 3.8 cm (-3.8 ± 7.5 cm; P = .003).
Conclusion
TRE improved β-cell function and insulin resistance in overweight patients with early diabetes, accompanied by beneficial effects on adiposity.
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