Cruciferous vegetables lower blood pressure in adults with mildly elevated blood pressure in a randomized, controlled, crossover trial: the VEgetableS for vaScular hEaLth (VESSEL) study
Connolly EL, Liu AH, Radavelli-Bagatini S, Shafaei A, Boyce MC, Wood LG, McCahon L, Koch H, Sim M, Hill CR, Parmenter BH, Bondonno NP, Devine A, Croft KD, Mithen R, Gan SK, Schultz CJ, Woodman RJ, Bondonno CP, Lewis JR, Hodgson JM, Blekkenhorst LC
BMC medicine · 13 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Australian Government
- Organización sin fines de lucro
- National Heart Foundation of Australia
- Universidad u hospital
- Edith Cowan University
- Gobierno
- Medical Research Council
- Gobierno
- National Health and Medical Research Council
- Subvenciones
- Edith Cowan University (G1004405); National Heart Foundation of Australia (102817); National Heart Foundation of Australia (ID: 102817); National Heart Foundation of Australia (102498); National Heart Foundation of Australia (CAF 130/2020); National Heart Foundation of Australia (1172987); National Health and Medical Research Council (1172987)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2024-09-02 · BMC Med · vol. 22 · número 1 · pág. 353
- Editorial
- BioMed Central
- Citado
- 16 citas · más que el 96% de estudios similares · 4.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 55 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Blood Pressure and Hypertension Studies · Sodium Intake and Health · Nutritional Studies and Diet
- Palabras clave
- cruciferous vegetables, blood pressure, dietary intervention, carotenoids, ambulatory blood pressure, dietary adherence, cardiovascular risk, older adults, hypertension prevention, dietary bioactive compounds, dietary fat, dietary protein, dietary sodium, potassium intake, dietary magnesium
- MeSH
- humans, vegetables, hypertension, cross-over studies, blood pressure, aged, middle aged, australia, female, male
22 autores
- Emma L. Connolly🇦🇺Edith Cowan University; RPH Research Foundation
- Alex H. Liu🇦🇺Edith Cowan University; RPH Research Foundation
- Simone Radavelli‐Bagatini🇦🇺Edith Cowan University; RPH Research Foundation
- Armaghan Shafaei🇦🇺Edith Cowan University
- Mary C. Boyce🇦🇺Edith Cowan University
- Lisa G. Wood🇦🇺University of Newcastle Australia
- Lyn McCahon🇦🇺Edith Cowan University; RPH Research Foundation
- Henrietta Koch🇦🇺The University of Western Australia; Royal Perth Hospital
- Marc Sim🇦🇺Edith Cowan University; The University of Western Australia; RPH Research Foundation
- Caroline R. Hill🇦🇺Edith Cowan University; RPH Research Foundation
- Benjamin Haddon Parmenter🇦🇺Edith Cowan University; RPH Research Foundation
- Nicola P. Bondonno🇦🇺Edith Cowan University; RPH Research Foundation
- Amanda Devine🇦🇺Edith Cowan University; RPH Research Foundation
- Kevin D. Croft🇦🇺The University of Western Australia; Royal Perth Hospital
- Richard F. Mithen🇳🇿University of Auckland
- Seng Khee Gan🇦🇺The University of Western Australia; Royal Perth Hospital
- Carl Johann Schultz🇦🇺The University of Western Australia; Royal Perth Hospital
- Richard John Woodman🇦🇺Flinders University
- Catherine P. Bondonno🇦🇺Edith Cowan University; The University of Western Australia; RPH Research Foundation
- Joshua Richard Lewis🇦🇺Edith Cowan University; The University of Sydney; The University of Western Australia; Children's Hospital at Westmead; RPH Research Foundation
- Jonathan M. Hodgson🇦🇺Edith Cowan University; The University of Western Australia; RPH Research Foundation
- Lauren C. Blekkenhorst🇦🇺 · autor de correspondenciaEdith Cowan University; The University of Western Australia; RPH Research Foundation
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Higher cruciferous vegetable intake is associated with lower cardiovascular disease risk in observational studies. The pathways involved remain uncertain. We aimed to determine whether cruciferous vegetable intake (active) lowers 24-h brachial systolic blood pressure (SBP; primary outcome) compared to root and squash vegetables (control) in Australian adults with mildly elevated BP (SBP 120-160 mmHg inclusive).
Methods
In this randomized, controlled, crossover trial, participants completed two 2-week dietary interventions separated by a 2-week washout. Cruciferous vegetables were compared to root and squash vegetables (~ 300 g/day) consumed with lunch and dinner meals. Participants were blinded to which interventions were the active and control. Adherence was assessed using food diaries and biomarkers (S-methyl cysteine sulfoxide (SMCSO, active) and carotenoids (control)). Twenty-four-hour brachial ambulatory SBP and secondary outcomes were assessed pre- and post each intervention. Differences were tested using linear mixed effects regression.
Results
Eighteen participants were recruited (median (IQR) age: 68 (66-70); female: n = 16/18; mean ± SD clinic SBP: 135.9 ± 10.0 mmHg). For both interventions, 72% participants had 100% adherence (IQR: 96.4-100%). SMCSO and carotenoids were significantly different between interventions (mean difference active vs. control SMCSO: 22.93 mg/mL, 95%CI 15.62, 30.23, P < 0.0001; carotenoids: - 0.974 mg/mL, 95%CI - 1.525, - 0.423, P = 0.001). Twenty-four-hour brachial SBP was significantly reduced following the active vs. control (mean difference - 2.5 mmHg, 95%CI - 4.2, - 0.9, P = 0.002; active pre: 126.8 ± 12.6 mmHg, post: 124.4 ± 11.8 mmHg; control pre: 125.5 ± 12.1 mmHg, post: 124.8 ± 13.1 mmHg, n = 17), driven by daytime SBP (mean difference - 3.6 mmHg, 95%CI - 5.4, - 1.7, P < 0.001). Serum triglycerides were significantly lower following the active vs. control (mean difference - 0.2 mmol/L, 95%CI - 0.4, - 0.0, P = 0.047).
Conclusions
Increased intake of cruciferous vegetables resulted in reduced SBP compared to root and squash vegetables. Future research is needed to determine whether targeted recommendations for increasing cruciferous vegetable intake benefits population health.
Trial registration
Clinical trial registry ACTRN12619001294145. https://www.anzctr.org.au.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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