Effects of time-restricted eating and low-carbohydrate diet on psychosocial health and appetite in individuals with metabolic syndrome: A secondary analysis of a randomized controlled trial
Zheng Y, Wang X, Wang J, Yang J, Wang T, Li Q, Zhu W, Wang Y, Sui J, Qiang W, Guo H, Wang Y, Shi B, He M
Clinical nutrition (Edinburgh, Scotland) · 13 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Recruitment Program of Global Experts
- Gobierno
- Key Research and Development Projects of Shaanxi Province
- Subvenciones
- Key Research and Development Projects of Shaanxi Province (2023-ZDLSF-40)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2024-08-30 · Clin Nutr · vol. 43 · número 10 · págs. 2316–2324
- Editorial
- Elsevier BV
- Citado
- 15 citas · más que el 94% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 59 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Regulation of Appetite and Obesity
- Palabras clave
- time-restricted eating, low-carbohydrate diet, metabolic syndrome, psychosocial health, quality of life, appetite, satiety, sleep quality, mood, depression, anxiety, stress, glucagon-like peptide-1, pancreatic polypeptide, peptide YY, leptin, amylin, dietary habits, weight loss, cardiometabolic parameters
- MeSH
- humans, feeding behavior, affect, appetite, sleep, quality of life, adult, middle aged, female, male, diet, carbohydrate-restricted, glucagon-like peptide 1, metabolic syndrome
14 autores
- Yixuan Zheng🇨🇳First Affiliated Hospital of Xi'an Jiaotong University
- Xin Wang🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; First Hospital of Xi'an
- Jingya Wang🇨🇳Xi’an Children’s Hospital; Xi'an Jiaotong University
- Jing Yang🇨🇳First Affiliated Hospital of Xi'an Jiaotong University
- Ting Wang🇨🇳Shaanxi Provincial People's Hospital
- Qian Li🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; First Hospital of Xi'an
- Wenzhi Zhu🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; First Hospital of Xi'an
- Yue Wang🇨🇳First Affiliated Hospital of Xi'an Jiaotong University
- Jing Sui🇨🇳First Affiliated Hospital of Xi'an Jiaotong University
- Wei Qiang🇨🇳First Affiliated Hospital of Xi'an Jiaotong University
- Hui Guo🇨🇳First Affiliated Hospital of Xi'an Jiaotong University
- Yanan Wang🇨🇳First Affiliated Hospital of Xi'an Jiaotong University
- Bingyin Shi🇨🇳First Affiliated Hospital of Xi'an Jiaotong University
- Mingqian He🇨🇳 · autor de correspondenciaFirst Affiliated Hospital of Xi'an Jiaotong University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aims
Time-restricted eating (TRE) and low-carbohydrate diet (LCD) can improve multiple cardiometabolic parameters in patients with metabolic syndrome (MetS), but their effects on psychosocial health and satiety are unclear. In this study, we aimed to evaluate the effects of TRE, LCD, and their combination (TRE + LCD) on quality of life (QoL), sleep, mood, appetite, and metabolic hormones in patients with MetS.
Methods
This is a secondary analysis of a single-center, 3-month, open-label, randomized clinical trial investigating the effects of TRE, LCD, and TRE + LCD on weight and cardiometabolic parameters in individuals with MetS. This secondary analysis examined QoL, sleep, mood, and appetite using the Rand 36-Item Short Form (SF-36); Pittsburgh Sleep Quality Index (PSQI); Depression, Anxiety, and Stress Scale; and Eating Behavior Rating Scale, respectively, as well as measured levels of metabolic hormones including leptin, amylin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1 (GLP-1), pancreatic polypeptide (PP), and peptide YY. Between-group comparisons were conducted via one-way ANOVAs and post hoc LSD tests for normally distributed variables or Kruskal‒Wallis H tests and the Nemenyi test for abnormally distributed variables. P < 0.017 was considered significant in multiple comparisons following Bonferroni adjustment.
Results
A total of 162 participants (mean [SD] age, 41.2 [9.9] years; mean [SD] body mass index, 29.3 [3.4] kg/m2; 102 [63%] men) who started the intervention were analyzed. After 3 months, only the TRE group decreased GLP-1 levels (-0.9 [IQR, -1.9 to -0.3] pg/mL; P = 0.002), increased PP levels (8.9 [IQR, -7.6 to 71.8] pg/mL; P = 0.011), physical functioning in the SF-36 (5.2 [95% CI, 1.9 to 8.5]; P = 0.001), social functioning in the SF-36 (9.1 [95% CI, 2.5 to 15.6]; P = 0.005), role-physical in the SF-36 (24.1 [95% CI, 11.8 to 36.4]; P < 0.001), role-emotional in the SF-36 (22.4 [95% CI, 12.6 to 32.2]; P < 0.001), and sleep efficiency in the PSQI (0.29 [95% CI, 0.03 to 0.55]; P = 0.021). Compared with changes in LCD, TRE further increased general health in the SF-36 (9.7 [95% CI, 3.3 to 16.0]; P = 0.006). Relative to the changes of TRE + LCD, TRE significantly increased role-emotional in the SF-36 (19.9 [95% CI 4.9 to 34.8]; P = 0.006). Changes in sleep quality, mood status, appetite, and metabolic hormones did not differ among three groups. Greater weight loss was associated with decreased leptin levels (r = 0.538), decreased amylin levels (r = 0.294), reduced total appetite scores (r = 0.220), and improved general health (r = -0.253) (all P ≤ 0.01).
Conclusions
TRE, LCD, and TRE + LCD all could improve psychosocial health and reduce appetite. Notably, TRE yielded greater benefits in QoL compared with LCD or TRE + LCD in individuals with MetS.
Trial registration
ClinicalTrials.gov Identifier: NCT04475822.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.