Time-restricted eating with or without a low-carbohydrate diet improved myocardial status and thyroid function in individuals with metabolic syndrome: secondary analysis of a randomized clinical trial
Zheng Y, Wang J, Liu M, Zhou X, Lin X, Liang Q, Yang J, Zhang M, Chen Z, Li M, Wang Y, Sui J, Qiang W, Guo H, Shi B, He M
BMC medicine · 9 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Key Research and Development Projects of Shaanxi Province
- Subvenciones
- Key Research and Development Projects of Shaanxi Province (2023-ZDLSF-40)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-09-04 · BMC Med · vol. 22 · número 1 · pág. 362
- Editorial
- BioMed Central
- Citado
- 11 citas · más que el 90% de estudios similares · 2.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 55 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- time-restricted eating, low-carbohydrate diet, metabolic syndrome, myocardial function, thyroid function, thyroid autoantibodies, thyroid-stimulating hormone, creatine kinase, lactate dehydrogenase, cardiac enzymes, obesity, weight loss, T3/T4 ratio, diet-induced weight loss, cardiometabolic risk factors, thyroglobulin antibodies
- MeSH
- myocardium, thyroid gland, humans, thyroid function tests, adult, aged, middle aged, female, male, diet, carbohydrate-restricted, metabolic syndrome
16 autores
- Yixuan Zheng🇨🇳First Affiliated Hospital of Xi'an Jiaotong University
- Jingya Wang🇨🇳Xi’an Children’s Hospital; Xi'an Jiaotong University
- Mengmeng Liu🇨🇳First Affiliated Hospital of Xi'an Jiaotong University
- Xingchen Zhou🇨🇳First Affiliated Hospital of Xi'an Jiaotong University
- Xiaoying Lin🇨🇳First Affiliated Hospital of Xi'an Jiaotong University
- Qian Liang🇨🇳First Affiliated Hospital of Xi'an Jiaotong University
- Jing Yang🇨🇳First Affiliated Hospital of Xi'an Jiaotong University
- Meng Zhang🇨🇳First Affiliated Hospital of Xi'an Jiaotong University
- Ziyi Chen🇨🇳First Affiliated Hospital of Xi'an Jiaotong University
- Meng Li🇨🇳First Affiliated Hospital of Xi'an Jiaotong University
- Yue Wang🇨🇳First Affiliated Hospital of Xi'an Jiaotong University
- Jing Sui🇨🇳First Affiliated Hospital of Xi'an Jiaotong University
- Wei Qiang🇨🇳First Affiliated Hospital of Xi'an Jiaotong University
- Hui Guo🇨🇳First Affiliated Hospital of Xi'an Jiaotong University
- Bingyin Shi🇨🇳 · autor de correspondenciaFirst Affiliated Hospital of Xi'an Jiaotong University
- Mingqian He🇨🇳 · autor de correspondenciaFirst Affiliated Hospital of Xi'an Jiaotong University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Obesity and metabolic syndrome (MetS) have become urgent worldwide health problems, predisposing patients to unfavorable myocardial status and thyroid dysfunction. Low-carbohydrate diet (LCD) and time-restricted eating (TRE) have been confirmed to be effective methods for weight management and improving MetS, but their effects on the myocardium and thyroid are unclear.
Methods
We conducted a secondary analysis in a randomized clinical diet-induced weight-loss trial. Participants (N = 169) diagnosed with MetS were randomized to the LCD group, the 8 h TRE group, or the combination of the LCD and TRE group for 3 months. Myocardial enzymes and thyroid function were tested before and after the intervention. Pearson's or Spearman's correlation was assessed between functions of the myocardium and thyroid and cardiometabolic parameters at baseline.
Results
A total of 162 participants who began the trial were included in the intention-to-treat (ITT) analysis, and 57 participants who adhered to their assigned protocol were involved in the per-protocol (PP) analysis. Relative to baseline, lactate dehydrogenase, creatine kinase MB, hydroxybutyrate dehydrogenase, and free triiodothyronine (FT3) declined, and free thyroxine (FT4) increased after all 3 interventions (both analyses). Creatine kinase (CK) decreased only in the TRE (- 18 [44] U/L, P < 0.001) and combination (- 22 [64] U/L, P = 0.003) groups (PP analysis). Thyrotropin (- 0.24 [0.83] μIU/mL, P = 0.011) and T3 (- 0.10 ± 0.04 ng/mL, P = 0.011) decreased in the combination group (ITT analysis). T4 (0.82 ± 0.39 μg/dL, P = 0.046), thyroglobulin antibodies (TgAb, 2 [1] %, P = 0.021), and thyroid microsomal antibodies (TMAb, 2 [2] %, P < 0.001) increased, while the T3/T4 ratio (- 0.01 ± 0.01, P = 0.020) decreased only in the TRE group (PP analysis). However, no significant difference between groups was observed in either analysis. At baseline, CK was positively correlated with the visceral fat area. FT3 was positively associated with triglycerides and total cholesterol. FT4 was negatively related to insulin and C-peptide levels. TgAb and TMAb were negatively correlated with the waist-to-hip ratio.
Conclusions
TRE with or without LCD confers remarkable metabolic benefits on myocardial status and thyroid function in subjects with MetS.
Trial registration
ClinicalTrials.gov, NCT04475822.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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