Asian Low-Carbohydrate Diet with Increased Whole Egg Consumption Improves Metabolic Outcomes in Metabolic Syndrome: A 52-Week Intervention Study
Pinsawas B, Surawit A, Mongkolsucharitkul P, Pongkunakorn T, Suta S, Manosan T, Ophakas S, Pumeiam S, Sranacharoenpong K, Mayurasakorn K
The Journal of nutrition · 13 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Mahidol University
Según 1 financiador declarado.
Publicación
- Publicado
- 2024-09-07 · J Nutr · vol. 154 · número 11 · págs. 3331–3345
- Editorial
- Elsevier BV
- Citado
- 19 citas · más que el 95% de estudios similares · 4.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 53 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Diet and metabolism studies · Nutritional Studies and Diet · Diet, Metabolism, and Disease
- Palabras clave
- Metabolic syndrome, Carbohydrate, Food science, Medicine, Biology, Internal medicine, Physiology, Endocrinology, Obesity
- MeSH
- egg yolk, humans, insulin resistance, obesity, triglycerides, eggs, adult, middle aged, female, male, diet, carbohydrate-restricted, waist circumference, metabolic syndrome, diet, ketogenic
10 autores
- Bonggochpass Pinsawas🇹🇭Siriraj Hospital; Mahidol University
- Apinya Surawit🇹🇭Siriraj Hospital; Mahidol University
- Pichanun Mongkolsucharitkul🇹🇭Siriraj Hospital; Mahidol University
- Tanyaporn Pongkunakorn🇹🇭Siriraj Hospital; Mahidol University
- Sophida Suta🇹🇭Siriraj Hospital; Mahidol University
- Thamonwan Manosan🇹🇭Siriraj Hospital; Mahidol University
- Suphawan Ophakas🇹🇭Siriraj Hospital; Mahidol University
- Sureeporn Pumeiam🇹🇭Siriraj Hospital; Mahidol University
- Kitti Sranacharoenpong🇹🇭 · autor de correspondenciaMahidol University
- Korapat Mayurasakorn🇹🇭 · autor de correspondenciaSiriraj Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The low-carbohydrate-ketogenic diet, an effective strategy to address metabolic syndrome (MetS) and obesity has raised concerns about high-fat consumption on atherogenic lipoproteins.
Objective
The aim of this study was to compare the Asian ketogenic diet (AKD), which incorporates balanced protein and fat intake from Asian foods, with a balanced low-caloric diet (BLC) in individuals diagnosed with MetS.
Methods
A 52-wk randomized clinical trial included 3 parallel groups: AKD with increased whole egg intake [egg yolk Asian ketogenic diet (Yolk-AKD, n = 28)], yolk-free ketogenic diet with egg white supplementation [egg white Asian ketogenic diet (White-AKD, n = 26)], and BLC (n = 22). Primary outcomes were anthropometric and metabolic changes.
Results
The AKD groups achieved significant reductions in weight and waist circumference (P < 0.05). Compared with the BLC group, the AKD groups demonstrated significant improvements in insulin resistance at week 6 and in triglyceride concentrations at weeks 12 (Yolk-AKD) and 35 (White-AKD) (P < 0.05). The AKD groups experienced improvements in hormones associated with insulin sensitivity and appetite, whereas only the Yolk-AKD group had a significant decrease in inflammation-related hormones (P < 0.05). From weeks 35-52, the AKD maintained reductions in anthropometric measurements, blood pressure, improved glucose tolerance, enhanced lipid profiles, and better liver function compared with the BLC.
Conclusions
The AKD proved safe and effective, yielding various metabolic improvements in individuals with MetS compared with the BLC. Emphasizing a low-saturated fat diet while disregarding dietary cholesterol, this approach holds promise for MetS and obesity management. The inclusion of both White-AKD and Yolk-AKD groups allowed for a comprehensive assessment of the AKD's impact, elucidating the differential effects of whole egg consumption on metabolic outcomes. Further studies are warranted. This trial was registered at clinicaltrials.gov as NCT04608136.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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