Preworkout dietary nitrate magnifies training-induced benefits to physical function in late postmenopausal women: a randomized pilot study
Carter SJ, Blechschmid TH, Baranauskas MN, Long EB, Gruber AH, Raglin JS, Lim K, Coggan AR
American journal of physiology. Regulatory, integrative and comparative physiology · 5 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NCATS NIH HHS
- Gobierno
- HHS | National Institutes of Health (NIH)
- Gobierno
- NHLBI NIH HHS
- Gobierno
- HHS | National Institutes of Health
- Subvenciones
- National Center for Advancing Translational Sciences (UL1TR002529); National Heart, Lung, and Blood Institute (R33 HL155858); National Institutes of Health (UL1 TR002529)
Según 7 financiadores declarados.
Publicación
- Publicado
- 2024-09-09 · Am J Physiol Regul Integr Comp Physiol · vol. 327 · número 6 · págs. R534–R542
- Editorial
- American Physiological Society
- Citado
- 8 citas · más que el 92% de estudios similares · 3.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 63 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Cardiovascular and exercise physiology · Exercise and Physiological Responses · Muscle metabolism and nutrition
- Palabras clave
- dietary nitrate, beetroot juice, postmenopausal women, exercise training, physical function, cardiorespiratory fitness, recovery, menopause, aging, circuit training
- MeSH
- humans, beta vulgaris, nitrates, pilot projects, oxygen consumption, postmenopause, heart rate, exercise tolerance, dietary supplements, aged, middle aged, female, circuit-based exercise, fruit and vegetable juices
8 autores
- Stephen J. Carter🇺🇸Indiana University Bloomington; Indiana University Melvin and Bren Simon Comprehensive Cancer Center; Indiana University
- Tyler H. Blechschmid🇺🇸Indiana University Bloomington; Indiana University
- Marissa N. Baranauskas🇺🇸University of Colorado Colorado Springs
- Emily B. Long🇺🇸Indiana University Bloomington; Indiana University
- Allison H. Gruber🇺🇸Indiana University Bloomington; Indiana University
- John S. Raglin🇺🇸Indiana University Bloomington; Indiana University
- Kenneth Lim🇺🇸Indiana University Indianapolis; Indiana University School of Medicine
- Andrew R. Coggan🇺🇸Indiana University Indianapolis; Indiana University School of Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
To inform end points for future work, we explored the utility of preworkout (i.e., an acute dose before training) beetroot juice (BRJ) combined with exercise (BRJ + EX) to augment indices of physical function in postmenopausal women compared with exercise only (EX). A two-arm pilot study was used to compare 24 postmenopausal women following an 8-wk, circuit-based exercise intervention. Participants were randomized to BRJ + EX (n = 12) or EX (n = 12). BRJ + EX participants consumed 140 mL of BRJ 120-180 min (only) before training for 7 wk, then discontinued during the final week to mitigate carryover effects. Physical function indices were 6-min walk test (6MWT), estimated V̇o2peak, heart rate recovery (HRR), and maximal knee extensor power (Pmax). A treadmill task was used to measure V̇o2 on-kinetics wherein mean response time (MRT) coincided with the duration to reach 63% of steady-state V̇o2. Results showed greater changes (Δ) among BRJ + EX participants for 6MWT distance (40 ± 23 m vs. 8 ± 25 m; P = 0.003, d = 1.35), ΔV̇o2peak (1.5 ± 0.9 mL·kg-1·min-1 vs. 0.3 ± 1.0 mL·kg-1·min-1; P = 0.008, d = 1.20), and ΔHRR (-10 ± 6 beats/min vs. -1 ± 9 beats/min; P = 0.017, d = 1.05). Large and medium effect sizes favoring BRJ + EX were detected for ΔPmax (P = 0.07, d = 0.83) and ΔMRT (P = 0.257, d = 0.50), respectively. In postmenopausal women, BRJ + EX appears to magnify some adaptive benefits to physical function including aerobic capacity and recovery beyond that of training without BRJ. Investigation into contributing mechanisms is needed.NEW & NOTEWORTHY Though exercise training represents the principal strategy to combat age-related decline, the attendant effects of menopause weaken aspects of exercise adaptation compared with premenopausal women and age-matched men. Here we provide important initial evidence that preworkout (i.e., an acute dose before training) beetroot juice coupled with an 8-wk, circuit-based exercise training intervention may uniquely benefit late postmenopausal women by enhancing indices of physical function including aerobic capacity and recovery.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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