Comprehensive modulatory effects of whole grain consumption on immune-mediated inflammation in middle-aged and elderly community residents: A real-world randomized controlled trial
Li C, Li Y, Wang N, Ge Z, Wang J, Ding B, Bi Y, Wang Y, Wang Y, Peng Z, Yang X, Wang C, Hong Z
Redox biology · 11 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Capital Medical University
- Universidad u hospital
- Beijing Friendship Hospital, Capital Medical University
- Universidad u hospital
- Capital Medical University Affiliated Beijing Friendship Hospital
- Subvenciones
- Beijing Friendship Hospital, Capital Medical University (BFHOS20230001); Beijing Friendship Hospital, Capital Medical University (YYZZ202137)
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-09-06 · Redox Biol · vol. 76 · pág. 103337
- Editorial
- Elsevier BV
- Citado
- 14 citas · más que el 93% de estudios similares · 3.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Nutrition and Health in Aging · GDF15 and Related Biomarkers · Nutritional Studies and Diet
- Palabras clave
- Whole grains, Inflammation, Immune system, Consumption (sociology), Context (archaeology), Population, Medicine, Environmental health, Immunology, Biology, Food science
- MeSH
- cd4-positive t-lymphocytes, humans, inflammation, cytokines, diet, dietary fiber, aged, middle aged, female, male, whole grains, interleukin-22
13 autores
- Cheng Li🇨🇳Capital Medical University; Beijing Friendship Hospital
- Yaru Li🇨🇳Capital Medical University; Beijing Friendship Hospital
- Nan Wang🇨🇳Capital Medical University; Beijing Friendship Hospital
- Zhiwen Ge🇨🇳Capital Medical University; Beijing Friendship Hospital
- Jia Wang🇨🇳Capital Medical University; Beijing Friendship Hospital
- Bingjie Ding🇨🇳Capital Medical University; Beijing Friendship Hospital
- Yanxia Bi🇨🇳Capital Medical University; Beijing Friendship Hospital
- Yuxia Wang🇨🇳Capital Medical University; Beijing Friendship Hospital
- Yisi Wang🇨🇳Capital Medical University; Beijing Friendship Hospital
- Zebin Peng🇨🇳Capital Medical University; Beijing Friendship Hospital
- Xinli Yang🇨🇳Capital Medical University; Beijing Friendship Hospital
- Congcong Wang🇨🇳Capital Medical University; Beijing Friendship Hospital
- Zhongxin Hong🇨🇳 · autor de correspondenciaBeijing Friendship Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aims
Whole grain consumption is widely recognized as a vital component of a balanced diet. Dietary fiber has been well-documented to play a crucial role in these health benefits attributed to whole grain intake. However, population-based evidence directly linking whole grain consumption to anti-inflammatory effects, especially in the context of immune-mediated inflammation, remains limited. We hypothesized that whole grain consumption promotes health by modulating immune-mediated inflammation.
Methods and results
This study was designed as a real-world, population-based randomized controlled trial. We compared the effects of whole grain versus refined grain consumption on immune-mediated inflammation through staple food substitution, while participants maintained their usual dietary practices. The results demonstrated that whole grain consumption significantly reduced circulating levels of pro-inflammatory cytokines IL-22 and IL-23 compared to refined grain consumption. These reductions were associated with optimized short-chain fatty acid profiles and changes in CD4+ T cell subset distributions.
Conclusions
The findings suggest that the anti-inflammatory effects of whole grain consumption in middle-aged and elderly populations are mediated by targeting specific CD4+ T cell subsets, in addition to modulating both upstream short-chain fatty acid composition and downstream expression of the pro-inflammatory cytokines IL-22 and IL-23.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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