Effects of dietary interventions and intermittent fasting on HDL function in obese individuals with T2DM: a randomized controlled trial
Pammer A, Obermayer A, Stadler JT, Pferschy PN, Tripolt NJ, Habisch H, Madl T, Sourij H, Marsche G
Cardiovascular diabetology · 9 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Austrian Science Fund
- Gobierno
- Austrian Science Fund FWF
- Subvenciones
- Austrian Science Fund (KLI 851‐B); Austrian Science Fund (P28854); Austrian Science Fund (10.55776/DOC129)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-09-12 · Cardiovasc Diabetol · vol. 23 · número 1 · pág. 339
- Editorial
- BioMed Central
- Citado
- 14 citas · más que el 93% de estudios similares · 3.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Dietary Effects on Health · Diabetes, Cardiovascular Risks, and Lipoproteins · Paraoxonase enzyme and polymorphisms
- Palabras clave
- type 2 diabetes, intermittent fasting, alternate-day fasting, HDL function, apolipoprotein M, HDL cholesterol efflux capacity, paraoxonase 1, lecithin:cholesterol acyltransferase, cholesteryl ester transfer protein, dietary intervention, obesity, glycemic control, weight loss, lipoprotein subclasses, cardiovascular risk, insulin management
- MeSH
- humans, diabetes mellitus, type 2, obesity, weight loss, insulin, aryldialkylphosphatase, phosphatidylcholine-sterol o-acyltransferase, blood glucose, hypoglycemic agents, treatment outcome, caloric restriction, fasting, time factors, adult, aged, middle aged, female, male, cholesterol, hdl, cholesterol ester transfer proteins, biomarkers, diet, healthy, intermittent fasting
9 autores
- Anja Pammer🇦🇹Medical University of Graz
- Anna Maria Obermayer🇦🇹Medical University of Graz
- Julia T. Stadler🇦🇹Medical University of Graz
- Peter N. Pferschy🇦🇹Medical University of Graz
- Norbert Joachim Tripolt🇦🇹Medical University of Graz
- Hansjörg Habisch🇦🇹Medical University of Graz
- Tobias Madl🇦🇹Medical University of Graz; BioTechMed-Graz
- Harald Sourij🇦🇹 · autor de correspondenciaMedical University of Graz; BioTechMed-Graz
- Gunther Marsche🇦🇹 · autor de correspondenciaMedical University of Graz; BioTechMed-Graz
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Cardiovascular disease represents a significant risk factor for mortality in individuals with type 2 diabetes mellitus (T2DM). High-density lipoprotein (HDL) is believed to play a crucial role in maintaining cardiovascular health through its multifaceted atheroprotective effects and its capacity to enhance glycemic control. The impact of dietary interventions and intermittent fasting (IF) on HDL functionality remains uncertain. The objective of this study was to assess the effects of dietary interventions and IF as a strategy to safely improve glycemic control and reduce body weight on functional parameters of HDL in individuals with T2DM.
Methods
Before the 12-week intervention, all participants (n = 41) of the INTERFAST-2 study were standardized to a uniform basal insulin regimen and randomized to an IF or non-IF group. Additionally, all participants were advised to adhere to dietary recommendations that promoted healthy eating patterns. The IF group (n = 19) followed an alternate-day fasting routine, reducing their calorie intake by 75% on fasting days. The participants' glucose levels were continuously monitored. Other parameters were measured following the intervention: Lipoprotein composition and subclass distribution were measured by nuclear magnetic resonance spectroscopy. HDL cholesterol efflux capacity, paraoxonase 1 (PON1) activity, lecithin cholesterol acyltransferase (LCAT) activity, and cholesterol ester transfer protein (CETP) activity were assessed using cell-based assays and commercially available kits. Apolipoprotein M (apoM) levels were determined by ELISA.
Results
Following the 12-week intervention, the IF regimen significantly elevated serum apoM levels (p = 0.0144), whereas no increase was observed in the non-IF group (p = 0.9801). ApoM levels correlated with weight loss and fasting glucose levels in the IF group. Both groups exhibited a robust enhancement in HDL cholesterol efflux capacity (p < 0.0001, p = 0.0006) after 12 weeks. Notably, only the non-IF group exhibited significantly elevated activity of PON1 (p = 0.0455) and LCAT (p = 0.0117) following the 12-week intervention. In contrast, the changes observed in the IF group did not reach statistical significance.
Conclusions
A balanced diet combined with meticulous insulin management improves multiple metrics of HDL function. While additional IF increases apoM levels, it does not further enhance other aspects of HDL functionality.
Trial registration
The study was registered at the German Clinical Trial Register (DRKS) on 3 September 2019 under the number DRKS00018070.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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