Impact of Magnesium Supplementation on Blood Pressure: An Umbrella Meta-Analysis of Randomized Controlled Trials
Alharran AM, Alzayed MM, Jamilian P, Prabahar K, Kamal AH, Alotaibi MN, Elshaer OE, Alhatm M, Masmoum MD, Hernández-Wolters B, Sindi R, Kord-Varkaneh H, Abu-Zaid A
Current therapeutic research, clinical and experimental · 14 citas
Cómo se estudió
- Diseño
- Metaanálisis (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-01-01 · Curr Ther Res Clin Exp · vol. 101 · pág. 100755
- Editorial
- Elsevier BV
- Citado
- 14 citas · más que el 80% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Sodium Intake and Health
- Palabras clave
- Meta-analysis, Randomized controlled trial, Magnesium, Blood pressure, Medicine, Internal medicine, Materials science, Metallurgy
13 autores
- Abdullah M Alharran🇧🇭Arabian Gulf University
- Mooza M Alzayed🇧🇭Arabian Gulf University
- Parsa Jamilian🇬🇧Keele University
- Kousalya Prabahar🇸🇦University of Tabuk
- Aminah Hassan Kamal🇸🇦King Faisal Specialist Hospital & Research Centre
- Muteb N Alotaibi🇸🇦Alfaisal University
- Omar E Elshaer🇸🇦Alfaisal University
- Mshal Alhatm🇸🇦Alfaisal University
- Mohd Diya Masmoum🇸🇦Alfaisal University
- Benjamin Hernández‐Wolters🇲🇽Universidad de Guadalajara
- Raghad Sindi🇸🇦Umm al-Qura University
- Hamed Kord‐Varkaneh🇮🇷 · autor de correspondenciaHamedan University of Medical Sciences; National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Ahmed Abu‐Zaid🇸🇦Alfaisal University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aim
Conflicting results on the effect of magnesium supplementation on blood pressure have been published in previous meta-analyses; hence, we conducted this umbrella meta-analysis of RCTs to provide a more robust conclusion on its effects.
Methods
Four databases including PubMed, Scopus, EMBASE, and Web of Science were searched to find pertinent papers published on international scientific from inception up to July 15, 2024. We utilized STATA version 17.0 to carry out all statistical analyses (Stata Corporation, College Station, TX, US). The random effects model was used to calculate the overall effect size ES and CI.
Findings
Ten eligible review papers with 8610 participants studied the influence of magnesium on SBP and DBP. The pooling of their effect sizes resulted in a significant reduction of SBP (ES = -1.25 mmHg; 95% CI: -1.98, -0.51, P = 0.001) and DBP (ES = -1.40 mmHg; 95% CI: -2.04, -0.75, P = 0.000) by magnesium supplementation. In subgroup analysis, a significant reduction in SBP and DBP was observed in magnesium intervention with dosage ≥400 mg/day (ES for SBP = -6.38 mmHg; ES for DBP = -3.71mmHg), as well as in studies with a treatment duration of ≥12 weeks (ES for SBP = -0.42 mmHg; ES for DBP = -0.45 mmHg).
Implications
The findings of the present umbrella meta-analysis showed an overall decrease of SBP and DBP with magnesium supplementation, particularly at doses of ≥400 mg/day for ≥12 weeks.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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