Effects of intermittent fasting and caloric restriction on inflammatory biomarkers in individuals with obesity/overweight: A systematic review and meta-analysis of randomized controlled trials
Aamir AB, Kumari R, Latif R, Ahmad S, Rafique N, Salem AM, Alasoom LI, Alsunni A, Alabdulhadi AS, Chander S
Obesity reviews : an official journal of the International Association for the Study of Obesity · 21 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2024-09-17 · Obes Rev · vol. 26 · número 1 · pág. e13838
- Editorial
- Wiley
- Citado
- 24 citas · más que el 86% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 55 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Dietary Effects on Health · Adipokines, Inflammation, and Metabolic Diseases · Exercise and Physiological Responses
- Palabras clave
- intermittent fasting, caloric restriction, obesity, overweight, low-grade inflammation, inflammatory markers, C-reactive protein, TNF-α, interleukin-6, ad libitum feeding
- MeSH
- humans, obesity, inflammation, c-reactive protein, caloric restriction, fasting, overweight, randomized controlled trials as topic, biomarkers, intermittent fasting
10 autores
- Ahmad Bin Aamir🇵🇰Punjab Medical College
- Roopa Kumari🇺🇸Mayo Clinic
- Rabia Latif🇸🇦 · autor de correspondenciaImam Abdulrahman Bin Faisal University
- Shakil Ahmad🇸🇦Imam Abdulrahman Bin Faisal University
- Nazish Rafique🇸🇦Imam Abdulrahman Bin Faisal University
- Ayad Mohammed Salem🇸🇦Imam Abdulrahman Bin Faisal University
- Lubna Ibrahim Al Asoom🇸🇦Imam Abdulrahman Bin Faisal University
- Ahmed Abdulrahman Alsunni🇸🇦Imam Abdulrahman Bin Faisal University
- Aseel Salah Alabdulhadi🇸🇦Imam Abdulrahman Bin Faisal University
- Subhash Chander🇺🇸Mayo Clinic
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Obesity is characterized by chronic low-grade inflammation. This study presents an updated systematic review and meta-analysis on the effect of caloric restriction (CR) and intermittent fasting (IF) on plasma inflammatory biomarkers (C-reactive protein [CRP], tumor necrosis factor [TNF]-alpha, and interleukin [IL]-6) in individuals with obesity/overweight compared with unrestricted or ad libitum feeding.
Methods
PubMed, Web of Science, and SCOPUS databases were searched for randomized controlled trials (RCTs) reporting inflammatory biomarkers after at least 8 weeks of intervention. Standardized mean differences (SMDs) were calculated using a fixed effect model. Heterogeneity was determined using I2 statistics. Sensitivity analysis was conducted using the "leave-one-out" approach.
Results
Relatively few RCTs have investigated the effect of IF on inflammatory biomarkers than with CR (6 vs. 15). Analysis of pooled data showed that CR was associated with a significant reduction in CRP with low heterogeneity (SMD -0.15 mg/L [95% CI -0.30 to -0.00], p = 0.04; I2 = 0%, p = 0.69) and IL-6 with high heterogeneity (SMD -0.31 pg/mL [95% CI -0.51 to -0.10], p = 0.004; I2 = 73%, p = 0.001). IF was associated with a significant decrease in TNF-alpha with moderate heterogeneity (SMD -0.32 pg/mL [95% CI -0.63 to -0.02], p = 0.04; I2 = 44%, p = 0.13). No associations were detected between IF and CRP or IL-6 and CR and TNF-alpha.
Conclusion
CR may be more effective in reducing chronic low-grade inflammation than IF. However, there were some concerns regarding the included studies' randomization and allocation sequence concealment process.
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