Unveiling the Effects of Cruciferous Vegetable Intake on Different Cancers: A Systematic Review and Dose-Response Meta-analysis
Zheng S, Yan J, Wang J, Wang X, Kang YE, Koo BS, Shan Y, Liu L
Nutrition reviews · 8 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Natural Science Foundation of Zhejiang Province
- Gobierno
- NSFC
- Subvenciones
- Natural Science Foundation of Zhejiang Province (LY21H260004); National Natural Science Foundation of China (82304149)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2024-09-30 · Nutr Rev · vol. 83 · número 5 · págs. 842–858
- Editorial
- Oxford University Press
- Citado
- 9 citas · más que el 54% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 257 trabajos
- Acceso
- De pago
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Phytochemicals and Antioxidant Activities · Glutathione Transferases and Polymorphisms
- Palabras clave
- Cruciferous vegetables, Medicine, Cancer, Cohort study, Cancer prevention, Meta-analysis, Prostate cancer, Odds ratio, Lung cancer, Internal medicine, Oncology
- MeSH
- humans, brassicaceae, vegetables, neoplasms, diet, female, male
8 autores
- Sicong Zheng🇰🇷🇨🇳Chungnam National University; Wenzhou Medical University
- Jielin Yan🇨🇳Wenzhou Medical University
- Jiaxin Wang🇨🇳Wenzhou Medical University
- Xinyi Wang🇨🇳Wenzhou Medical University
- Yea Eun Kang🇰🇷Chungnam National University
- Bon Seok Koo🇰🇷Chungnam National University
- Yujuan Shan🇨🇳 · autor de correspondenciaWenzhou Medical University
- Lihua Liu🇨🇳 · autor de correspondenciaWenzhou Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Epidemiological studies indicated that cruciferous vegetable intake is associated with positive health outcomes. However, the role of cruciferous vegetables may have differential impacts on various cancers.
Objective
This meta-analysis aims to review recent epidemiological studies on the link between cruciferous vegetables and various cancers. It seeks to identify the optimal intake dose and timing of cruciferous vegetables influencing their association with cancer risk.
Data sources
Studies on cruciferous vegetables and cancer were searched in PubMed, NCBI, Web of Science, and Elsevier databases from 1978 to June 2023.
Data extraction
Extracted data from 226 relevant case-control and cohort studies were expressed by standardized mean difference and 95% CI, followed by the subgroup analysis to eliminate heterogeneity.
Results
Intake of cruciferous vegetables can prevent cancers, with an odds ratio of 0.77 and risk ratio (RR) of 0.96. The intake levels of cruciferous vegetables associated with the risk of colorectal cancer, lung cancer, upper gastrointestinal cancer, gynecological cancer (ovarian cancer and endometrial cancer), bladder cancer, renal cancer, and prostate cancer were found to be 5.41 servings/week, 5.41 servings/week, 5.5 servings/week, 7.4 servings/week, 5.5 servings/week, 4.85 servings/week, and 3 servings/week, respectively. In a cohort followed for 2 to 15 years, limited consumption of cruciferous vegetables was correlated with a higher cancer RR. In the Asian population, cruciferous vegetables had a significant relationship with lung cancer, head and neck squamous cell carcinoma, and esophageal cancer. Conversely, cruciferous vegetables are predominantly associated with colorectal, renal, gynecological, and prostate cancer in the American population.
Conclusion
This study highlights the complex link between cruciferous vegetables and cancer, influenced by factors such as cancer type, region, intake level, and follow-up duration.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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