Effects of Ashwagandha (Withania Somnifera) on stress and anxiety: A systematic review and meta-analysis
Arumugam V, Vijayakumar V, Balakrishnan A, B Bhandari R, Boopalan D, Ponnurangam R, Sankaralingam Thirupathy V, Kuppusamy M
Explore (New York, N.Y.) · 16 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2024-09-21 · Explore (NY) · vol. 20 · número 6 · pág. 103062
- Editorial
- Elsevier BV
- Citado
- 32 citas · más que el 98% de estudios similares · 5.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 34 trabajos
- Acceso
- De pago
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Mindfulness and Compassion Interventions · Hallucinations in medical conditions
- Palabras clave
- Withania somnifera, Anxiety, Meta-analysis, Traditional medicine, Psychology, Medicine, Alternative medicine, Psychiatry, Internal medicine, Pathology
- MeSH
- humans, withania, plant extracts, phytotherapy, stress, psychological, anxiety, randomized controlled trials as topic
8 autores
- Velan Arumugam🇮🇳Tamil Nadu Dr. M.G.R. Medical University; Central Council for Research in Yoga & Naturopathy
- Venugopal Vijayakumar🇮🇳Central Council for Research in Yoga & Naturopathy
- Arthi Balakrishnan🇮🇳Tamil Nadu Dr. M.G.R. Medical University; Central Council for Research in Yoga & Naturopathy
- Rudra B. Bhandari🇮🇳Patanjali Research Foundation
- Deenadayalan Boopalan
- Ramesh Ponnurangam🇮🇳Tamil Nadu Dr. M.G.R. Medical University; Central Council for Research in Yoga & Naturopathy
- Venkateswaran Sankaralingam Thirupathy🇮🇳Tamil Nadu Dr. M.G.R. Medical University
- Maheshkumar Kuppusamy🇮🇳 · autor de correspondenciaCentral Council for Research in Yoga & Naturopathy
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Ashwagandha (Withania somnifera) is an adaptogenic herb used to prevent and treat psychosomatic disorders. This systematic review and meta-analysis evaluated the effects and safety of Ashwagandha on psychosomatic functions related to stress and anxiety among patients.
Methods
A comprehensive search was conducted in MEDLINE, EMBASE, PubMed, PsychINFO, and the Cochrane Library for articles published from January 2000 to January 2022. Randomized controlled trials that examined the effects of Ashwagandha on stress and anxiety were included. Two authors independently extracted all relevant data from the included studies. Both subjective and objective measures of stress and anxiety were assessed as outcome variables.
Result
Nine randomized controlled trials involving 558 patients were eligible for this study. The findings of the meta-analysis showed a significant effect of Ashwagandha formulations on the Perceived Stress Scale (PSS) (MD = -4.72, 95 % CI = [-8.45 to -0.99]), Hamilton Anxiety Scale (HAS) (MD = -2.19, 95 % CI = [-3.83 to -0.55]), and serum cortisol levels (MD = -2.58, 95 % CI = [-4.99 to -0.16]) compared to the placebo group. Among the included studies, four reported mild to moderate adverse events.
Conclusion
The findings from the included studies indicate that Ashwagandha formulations have beneficial effects on stress and anxiety. The adverse effects associated with Ashwagandha are limited; however, further information is required to determine its safety with long-term administration.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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