Creatine supplementation does not add to resistance training effects in prostate cancer patients under androgen deprivation therapy: A double-blind randomized trial
Fairman CM, Kendall KL, Newton RU, Hart NH, Taaffe DR, Lopez P, Chee R, Tang CI, Galvão DA
Journal of science and medicine in sport · 5 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Cancer Council Tasmania
- Organización sin fines de lucro
- Cancer Council Western Australia
Según 2 financiadores declarados.
Publicación
- Publicado
- 2024-09-14 · J Sci Med Sport · vol. 28 · número 2 · págs. 118–124
- Editorial
- Elsevier BV
- Citado
- 10 citas · más que el 85% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 43 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Muscle metabolism and nutrition · Nutrition and Health in Aging · Cancer survivorship and care
- Palabras clave
- creatine supplementation, resistance training, prostate cancer, androgen deprivation therapy, lean body mass, muscle strength, physical function, fat mass
- MeSH
- humans, prostatic neoplasms, creatine, androgen antagonists, double-blind method, body composition, dietary supplements, aged, aged, 80 and over, middle aged, male, muscle strength, resistance training
9 autores
- Ciaran M. Fairman🇦🇺🇺🇸Edith Cowan University; University of South Carolina
- Kristina L. Kendall🇦🇺Edith Cowan University
- Robert Usher Newton🇦🇺Edith Cowan University; The University of Queensland
- Nicolas H. Hart🇦🇺University of Technology Sydney; Edith Cowan University
- Dennis R. Taaffe🇦🇺Edith Cowan University
- Pedro López🇦🇺Institute for Respiratory Health
- Raphael Chee🇦🇺Edith Cowan University; The University of Western Australia; GenesisCare
- Colin Tang🇦🇺Edith Cowan University; Sir Charles Gairdner Hospital
- Daniel Abido Galvao🇦🇺 · autor de correspondenciaEdith Cowan University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Androgen deprivation therapy (ADT) leads to loss of lean mass (LM) and reduced strength and physical function. Resistance exercise alone can counteract these changes; however, it is unknown if the addition of creatine supplementation can further protect against these ADT-induced toxicities. We compared the effects of creatine supplementation with resistance exercise versus resistance exercise alone in patients with prostate cancer undergoing ADT on LM, muscle strength, and physical function.
Design
A 12-week randomized trial.
Methods
Men with prostate cancer receiving ADT (n = 30) were randomized to either resistance exercise + placebo (PLA) or resistance exercise + creatine (SUPP), with both groups undertaking supervised exercise 3 days per week. Outcomes included whole body and appendicular LM and fat mass (FM) assessed by dual-energy X-ray absorptiometry, as well as muscle strength (chest press, seated low, leg press), and physical function (timed up-and-go, chair rise, 400-m walk) assessed at baseline and following the intervention.
Results
Patients were aged 59-84 years with a BMI of 28.6 kg·m-2. PLA completed a mean of 30 sessions (83 %) and SUPP a mean of 33 sessions (92 %). Despite similar within-group improvements (p < 0.05) in whole-body LM (PLA +0.6 kg, SUPP +1.3 kg), appendicular LM (PLA +0.5 kg, SUPP +0.6 kg), muscle strength (PLA +8.8-49.3 kg, SUPP +9.4-40.4 kg) and physical function, there were no between group differences (p = 0.078-0.951). No adverse events were reported due to creatine supplementation or resistance exercise.
Conclusions
A short-term program of resistance exercise alone results in meaningful improvements in LM, muscle strength and physical function, with no additional effects of creatine supplementation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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