Dose and timing effects of caffeine on subsequent sleep: a randomized clinical crossover trial
Gardiner CL, Weakley J, Burke LM, Fernandez F, Johnston RD, Leota J, Russell S, Munteanu G, Townshend A, Halson SL
Sleep · 30 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-10-02 · Sleep · vol. 48 · número 4
- Editorial
- Oxford University Press
- Citado
- 38 citas · más que el 99% de estudios similares · 9.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 81 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Coffee research and impacts · Sleep and related disorders · Sleep and Work-Related Fatigue
- Palabras clave
- caffeine, dose-response relationship, bedtime, sleep quality, sleep architecture, sleep onset delay, sleep fragmentation, subjective sleep quality
- MeSH
- humans, caffeine, central nervous system stimulants, polysomnography, cross-over studies, double-blind method, sleep, dose-response relationship, drug, time factors, adult, male, young adult, sleep quality
10 autores
- Carissa Gardiner🇦🇺 · autor de correspondenciaAustralian Catholic University
- Jonathon J. S. Weakley🇬🇧🇦🇺Leeds Beckett University; Australian Catholic University
- Louise M. Burke🇦🇺Australian Catholic University
- Francesca Fernandez🇦🇺Australian Catholic University
- Rich D. Johnston🇬🇧🇦🇺Leeds Beckett University; Australian Catholic University
- Josh Leota🇦🇺Monash University
- Suzanna Russell🇦🇺Australian Catholic University
- Gabriella Munteanu🇦🇺Australian Catholic University
- ANDREW D. TOWNSHEND🇦🇺Australian Catholic University
- Shona Leigh Halson🇦🇺Australian Catholic University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Study objectives
To investigate the effect of a typical dose of caffeine and a high dose of caffeine consumed in the morning, afternoon, and evening on subsequent sleep.
Methods
Using a placebo-controlled, double-blind, randomized crossover design, 23 males (25.3 ± 5.0 years) with a moderate habitual caffeine intake (<300 mg∙day-1) completed seven conditions: placebo, and 100 and 400 mg of caffeine consumed 12, 8, and 4 hours prior to bedtime, with a 48-hour washout. In-home partial polysomnography and sleep diaries were used to assess sleep. Linear mixed models estimated the effect of each condition.
Results
No significant effect on objective or subjective sleep occurred with the 100 mg dose of caffeine compared with the placebo (p > .05), but significant effects occurred with the 400 mg dose (p < .05). Significant delays in sleep initiation and alterations to sleep architecture were observed when 400 mg was consumed within 12 hours of bedtime (p < .05), and significantly greater sleep fragmentation occurred when 400 mg was consumed within 8 hours of bedtime (p < .05). Additionally, perceived sleep quality was significantly reduced when 400 mg was consumed 4 hours prior to bedtime (-34.02%, p = .006) but not at 8 or 12 hours.
Conclusions
A 100 mg dose of caffeine can be consumed up to 4 hours prior to bedtime, but 400 mg may negatively impact sleep when consumed as one dose within 12 hours of bedtime, with the adverse influence on sleep increasing the closer consumption occurs to bedtime. The discrepancy between objective and subjective sleep quality suggests that individuals may have difficulty accurately perceiving the influence of caffeine on sleep quality.
Clinical trial registration
Australian and New Zealand Clinical Trials Registry, registration number: ACTRN12621001625864, https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12621001625864.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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