Development and feasibility testing of a time-restricted eating intervention for women living with overweight/obesity and HIV in a resource-limited setting of South Africa
Hoosen F, Pico ML, Goedecke JH, Dave JA, Quist JS, Færch K, Grunnet LG, de Villiers A, Aagaard-Hansen J, Mendham AE
BMC public health · 5 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Steno Diabetes Center Copenhagen
- Organización sin fines de lucro
- European Foundation for the Study of Diabetes
- Gobierno
- Fonds National de la Recherche Luxembourg
- Universidad u hospital
- Steno Diabetes Center Copenhagen (SDCC)
- Subvenciones
- Steno Diabetes Center Copenhagen (SDCC 2.G Reproduktiv sundhed og familier)
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-10-10 · BMC Public Health · vol. 24 · número 1 · pág. 2768
- Editorial
- BioMed Central
- Citado
- 6 citas · más que el 82% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 46 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Dietary Effects on Health · Eating Disorders and Behaviors · Diet and metabolism studies
- Palabras clave
- time-restricted eating, HIV, overweight and obesity, dolutegravir, weight management, women, food insecurity, intervention feasibility, intervention development, behaviour change theory, family support, adherence, appetite regulation, type 2 diabetes, resource-limited settings
- MeSH
- humans, hiv infections, obesity, oxazines, piperazines, pyridones, heterocyclic compounds, 3-ring, fasting, focus groups, feasibility studies, pilot projects, adult, middle aged, south africa, female, overweight, young adult, resource-limited settings, dolutegravir
10 autores
- Fatima Hoosen🇿🇦 · autor de correspondenciaUniversity of Cape Town; Sports Science Institute of South Africa
- Majken Lillholm Pico🇩🇰Steno Diabetes Center Copenhagen
- Julia H. Goedecke🇿🇦South African Medical Research Council; University of Cape Town; Sports Science Institute of South Africa
- Joel Alex Dave🇿🇦University of Cape Town; Groote Schuur Hospital
- Jonas Salling Quist🇩🇰🇬🇧University of Copenhagen; University of Leeds; Steno Diabetes Center Copenhagen
- Kristine Færch🇩🇰Steno Diabetes Center Copenhagen
- Louise Groth Grunnet🇩🇰Steno Diabetes Center Copenhagen
- Anniza de Villiers🇿🇦University of Cape Town; Sports Science Institute of South Africa
- Jens Aagaard‐Hansen🇿🇦🇩🇰South African Medical Research Council; University of the Witwatersrand; Steno Diabetes Center Copenhagen
- Amy E. Mendham🇿🇦🇦🇺University of Cape Town; Sports Science Institute of South Africa; Riverland Mallee Coorong Local Health Network
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Human Immunodeficiency Virus (HIV) and type 2 diabetes (T2D) are amongst the leading causes of death in South Africa. The preferred first-line anti-retroviral treatment contains dolutegravir (DTG), shown to increase body weight, may compound the already high rates of obesity and associated risk for T2D. South Africa has widespread food insecurity, making traditional dietary strategies difficult to implement. Time-restricted eating (TRE) may be an appropriate intervention in resource-limited communities.
Methods
This article outlines the development and feasibility testing of a TRE intervention to inform the design of a TRE randomised controlled trial in women (20-45 years old) living with overweight/obesity and HIV, receiving DTG-based treatment from a resource-limited community in Cape Town, South Africa. Factors influencing TRE adoption were identified using the Capability, Opportunity, Motivation - Behaviour model and the Theoretical Domains Framework, combining in-depth interviews (IDIs) and focus group discussions. Participants from the IDIs went on to participate in a single arm 4-week TRE pilot trial where feasibility was explored in terms of reach, acceptability, applicability, and implementation integrity. An iterative, thematic analysis approach was employed to analyse the qualitative data.
Results
Participants included 33 isiXhosa-speaking women (mean age 37.1 years, mean BMI 35.9 kg/m2). Thematic analysis identified psychological capability (knowledge of fasting), social influences (cultural preferences, family support), and reflective motivation (awareness of weight, health impact, motivation for TRE) as key factors influencing adoption of TRE for weight management. In a 4-week TRE pilot trial (n = 12), retention was 100%. Positive outcomes perceived included improved energy, appetite control and weight loss. TRE was perceived as acceptable, easy, and enjoyable. Family support facilitated adherence, while habitual and social eating and drinking practices were barriers. Compliance was high, aided by self-selected eating times, reminders, and weekly calls. Recommendations included the incorporation of dietary education sessions and text messages to provide additional support and reminders.
Conclusions
This study indicates that TRE is a feasible weight management strategy in women living with overweight/obesity and HIV, receiving DTG-based treatment in a resource-limited community. These findings will ensure that the forthcoming TRE randomised controlled trial is adapted and optimised to the local South African context.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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