Cold Exposure Therapy Sensitizes Nanodrug-Mediated Radioimmunotherapy of Breast Cancer
Qiao K, Pan Y, Zhang S, Shi G, Yang J, Zhang Z, Wang K, Chen X, Ning S
ACS nano · 21 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Natural Science Foundation of Guangxi Zhuang Autonomous Region
- Gobierno
- Ministry of Health -Singapore
- Universidad u hospital
- National University of Singapore
- Gobierno
- National Research Foundation Singapore
- Gobierno
- Ministry of Education - Singapore
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- National Medical Research Council
- Subvenciones
- National Medical Research Council ((MOH-001388-00); Ministry of Education - Singapore (MOE- 000387-00); National Research Foundation Singapore (NRF‐000352‐00); National University of Singapore (NUHSRO/2023/008/NUSMed/TCE/LOA); National Natural Science Foundation of China (82303500); National Medical Research Council (MOH‐001041); National University of Singapore (NUHSRO/2021/0 34/TRP/09/Nanomedicine); National Natural Science Foundation of China (82473348); Natural Science Foundation of Guangxi Zhuang Autonomous Region (2023GXNSFBA026137); National University of Singapore (NUHSRO/ 2020/133/Startup/08); Ministry of Health -Singapore (MOH- 001388-00); Ministry of Health -Singapore (CG21APR1005); Ministry of Health -Singapore (MOH-001041); National Medical Research Council (CG21APR1005); National Natural Science Foundation of China (82303797)
Según 7 financiadores declarados.
Publicación
- Publicado
- 2024-10-14 · ACS Nano · vol. 18 · número 43 · págs. 29689–29703
- Editorial
- American Chemical Society
- Citado
- 30 citas · más que el 94% de estudios similares · 3.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 65 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nanoplatforms for cancer theranostics · Cancer, Stress, Anesthesia, and Immune Response · Immune cells in cancer
- Palabras clave
- Cancer research, Peroxynitrite, Tumor microenvironment, Nitric oxide, Chemistry, Glutathione, Pharmacology, Superoxide, Medicine, Internal medicine, Biochemistry, Tumor cells
- MeSH
- cell line, tumor, animals, mice, inbred balb c, humans, mice, breast neoplasms, nitric oxide, antineoplastic agents, liposomes, radioimmunotherapy, cryotherapy, cell proliferation, female, nanoparticles, cold temperature
9 autores
- Kun Qiao🇨🇳Harbin Medical University; Third Affiliated Hospital of Harbin Medical University
- Pan You🇨🇳Guangxi Medical University
- Shiyuan Zhang🇨🇳Harbin Medical University; Third Affiliated Hospital of Harbin Medical University
- Guangfu Shi🇨🇳Guangxi Medical University
- Jinglin Yang🇨🇳Guangxi Medical University
- Zhenlin Zhang🇨🇳Guangxi Medical University
- Kaiyuan Wang🇨🇳🇸🇬 · autor de correspondenciaShenyang Pharmaceutical University; National University of Singapore
- Xiaoyuan Shawn Chen🇸🇬🇫🇷 · autor de correspondenciaAgency for Science, Technology and Research; National University of Singapore; Université Bourgogne Franche-Comté; Institute of Molecular and Cell Biology
- Shipeng Ning🇨🇳 · autor de correspondenciaGuangxi Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Cold exposure (CE) therapy can quickly induce tumor starvation by brown adipose tissue (BAT) thermogenesis. Exploring the combined antitumor mechanism of CE and traditional therapies (such as radiotherapy (RT)) is exciting and promising. In this study, we investigated the effect of CE in combination with nitric oxide (NO) gas therapy on sensitizing tumors to RT and promoting tumor radio-immunotherapy. We first constructed a liposome (SL) loaded with the NO prodrug S-nitroso-N-acetylpenicillamine (SNAP). When SL is injected, the glutathione (GSH) within the tumor region promotes the release of NO from SNAP. Subsequently, the superoxide anion produced by RT reacts with NO to generate peroxynitrite (ONOO-), which has strong oxidative properties and induces cell death. Meanwhile, the mice were exposed to a CE environment of 4 °C. CE-mediated BAT thermogenesis induced tumor starvation, which led to a decrease in ATP and GSH content within the tumor as well as an improvement in the hypoxic microenvironment and a decrease in myeloid-derived suppressor cells. All of the above have promoted the effectiveness of RT and activated the systemic antitumor immunity. In the bilateral tumor experiment, treatment of the primary tumor inhibited the growth of the distant tumor and promoted the infiltration of CD8+ T cells into the tumor. These findings reveal that the synergy of CE, NO gas therapy, and RT could confer high effective anticancer effects, providing possibilities in personalized cancer treatment.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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