Short-term intermittent fasting and energy restriction do not impair rates of muscle protein synthesis: A randomised, controlled dietary intervention
Kouw IWK, Parr EB, Wheeler MJ, Radford BE, Hall RC, Senden JM, Goessens JPB, van Loon LJC, Hawley JA
Clinical nutrition (Edinburgh, Scotland) · 7 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Australian Catholic University
- Organización sin fines de lucro
- European Society for Clinical Nutrition and Metabolism
Según 2 financiadores declarados.
Publicación
- Publicado
- 2024-09-26 · Clin Nutr · vol. 43 · número 11 · págs. 174–184
- Editorial
- Elsevier BV
- Citado
- 10 citas · más que el 89% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 48 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Dietary Effects on Health · Muscle metabolism and nutrition · Muscle Physiology and Disorders
- Palabras clave
- intermittent fasting, alternate-day fasting, caloric restriction, muscle protein synthesis, skeletal muscle, obesity, overweight, lean body mass, body composition, leptin, insulin, fasting blood glucose, gastrointestinal hormones, continuous glucose monitoring, protein intake
- MeSH
- muscle, skeletal, humans, obesity, muscle proteins, caloric restriction, fasting, body composition, energy intake, adult, middle aged, male, overweight, intermittent fasting
9 autores
- Imre W. K. Kouw🇦🇺 · autor de correspondenciaAustralian Catholic University
- Evelyn B. Parr🇦🇺Australian Catholic University
- Michael J. Wheeler🇦🇺Australian Catholic University
- Bridget E. Radford🇦🇺Australian Catholic University
- Rebecca C. Hall🇦🇺Australian Catholic University
- Joan M. Senden🇳🇱Maastricht University Medical Centre
- Joy P. B. Goessens🇳🇱Maastricht University Medical Centre
- Luc J. C. van Loon🇳🇱🇦🇺Maastricht University Medical Centre; Australian Catholic University
- John Alan Hawley🇬🇧🇦🇺Manchester Metropolitan University; Australian Catholic University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Intermittent fasting (IF) is an effective energy restricted dietary strategy to reduce body and fat mass and improve metabolic health in individuals with either an overweight or obese status. However, dietary energy restriction may impair muscle protein synthesis (MPS) resulting in a concomitant decline in lean body mass. Due to periods of prolonged fasting combined with irregular meal intake, we hypothesised that IF would reduce rates of MPS compared to an energy balanced diet with regular meal patterns.
Aims
We assessed the impact of a short-term, ten days, alternate day fasting or a continuous energy restricted diet to a control diet on integrated rates of skeletal MPS in middle-aged males with overweight or obesity.
Methods
Twenty-seven middle-aged males with overweight or obesity (age: 44.6 ± 5.4 y; BMI: 30.3 ± 2.6 kg/m2) consumed a three-day lead-in diet, followed by a ten-day controlled dietary intervention matched for protein intake, as alternate day fasting (ADF: 62.5 energy (En)%, days of 25 En% alternated with days of 100 En% food ingestion), continuous energy restriction (CER: 62.5 En%), or an energy balanced, control diet (CON: 100 En%). Deuterated water (D2O) methodology with saliva, blood, and skeletal muscle sampling were used to assess integrated rates of MPS over the ten-day intervention period. Secondary measures included fasting plasma glucose, insulin, and gastrointestinal hormone concentrations, continuous glucose monitoring, and assessment of body composition.
Results
There were no differences in daily rates of MPS between groups (ADF: 1.18 ± 0.13, CER: 1.13 ± 0.16, and CON: 1.18 ± 0.18 %/day, P > 0.05). The reductions in body mass were greater in ADF and CER compared to CON (P 0.05). Fasting plasma leptin concentrations decreased in ADF and CER (P < 0.001), with no differences in fasting plasma glucose or insulin concentrations between groups.
Conclusion
Short-term alternate day fasting does not lower rates of MPS compared to continuous energy restriction or an energy balanced, control diet with matched protein intake. The prolonged effects of IF and periods of irregular energy and protein intake patterns on muscle mass maintenance remain to be investigated. This trial was registered under Australian New Zealand Clinical Trial Registry (https://www.anzctr.org.au), identifier no. ACTRN12619000757112.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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