Axial Shortening Effects of Repeated Low-level Red-light Therapy in Children With High Myopia: A Multicenter Randomized Controlled Trial
Liu G, Liu L, Rong H, Li L, Liu X, Jia Z, Zhang H, Wang B, Song D, Hu J, Shi X, Du B, Wei R
American journal of ophthalmology · 28 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- National Key Clinical Specialty Discipline Construction Program of China
Según 2 financiadores declarados.
Publicación
- Publicado
- 2024-10-16 · Am J Ophthalmol · vol. 270 · págs. 203–215
- Editorial
- Elsevier BV
- Citado
- 47 citas · más que el 99% de estudios similares · 12.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 54 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Ophthalmology and Visual Impairment Studies · Retinopathy of Prematurity Studies · Corneal surgery and disorders
- Palabras clave
- Medicine, Randomized controlled trial, Ophthalmology, Internal medicine
- MeSH
- humans, myopia, degenerative, disease progression, tomography, optical coherence, refraction, ocular, treatment outcome, phototherapy, follow-up studies, single-blind method, visual acuity, child, female, male, axial length, eye
13 autores
- Guihua Liu🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Lin Liu🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Hua Rong🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Li Li🇨🇳Beijing Children’s Hospital
- Xuan Liu🇨🇳Beijing Tsinghua Chang Gung Hospital
- Zhiyang Jia🇨🇳Hospital of Hebei Province; Hebei General Hospital
- Hua Zhang🇨🇳First Hospital of Shijiazhuang
- Biying Wang🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Desheng Song🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Jiamei Hu🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Xinrui Shi🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Bei Du🇨🇳 · autor de correspondenciaTianjin Medical University Eye Hospital; Tianjin Medical University
- Ruihua Wei🇨🇳 · autor de correspondenciaTianjin Medical University Eye Hospital; Tianjin Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
To evaluate the effectiveness and safety of repeated low-level red-light (RLRL) in delaying the progression of high myopes with -6.00 diopters (D) or worse.
Design
Multicenter, randomized, parallel-group, single-blind clinical trial. A total of 202 high myopic children aged 7 to 12 years with cycloplegia spherical equivalent (SE) refraction ≤-6.00 D, astigmatism less than 2.50 D, and anisometropia of 1.50 D or less were enrolled from March 2022 to December 2022. Follow-up was completed in December 2023.
Methods
Eligible participants were randomly allocated to the intervention (RLRL + single vision spectacle) or the control group (single vision spectacle). The RLRL treatment was administered every day for 3 minutes, twice a day, with an interval of at least 4 hours. The primary outcome was the change in axial length (AL) at 12 months compared with baseline. Secondary outcomes included changes in SE, changes in choroidal thickness (ChT), and changes in retinal thickness (RT) in different circle sectors. Outcomes were analyzed by means of intention-to-treat and per-protocol methods.
Results
After 12 months of treatment, AL and SE changes were -0.11 ± 0.25 mm and 0.18 ± 0.63 D for the RLRL group and 0.32 ± 0.09 mm and -0.80 ± 0.42 D for the control group, respectively. Axial shortening >0.05 mm was 59% in the RLRL and 0% in the control group at 12 months. ChT and RT from a single center were analyzed. In the RLRL group, ChT was thickened in all sectors at 12 months. RT was increased in parafoveal and perifoveal circles. In the control group, all sectors of ChT and only perifoveal RT were significantly thinner at 12 months. The multivariate linear regression model revealed significant correlations between changes in the ChT central foveal circle and RT perifoveal circle at 1 month and AL changes at 12 months. No fundus structure changes, afterimage exceeding 6 minutes, or best-corrected visual acuity decrease were reported.
Conclusions
RLRL could effectively shorten the AL and inhibit the progression of myopia in high myopic patients with -6.00 D or worse. AL shortening is sustained over 12 months of treatment. These observed changes appeared to be associated with increases in ChT and RT.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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