Financiado en parte por American Pistachio Growers
Pistachio Consumption Increases Macular Pigment Optical Density in Healthy Adults: A Randomized Controlled Trial
Scott TM, Ogunbodede O, McKay DL, Johnson EJ
The Journal of nutrition · 3 citas
Etiquetas de revisión
Vínculos de autores con la industriaAlimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- U.S. Department of Agriculture
- Gobierno
- National Institutes of Health
- Gobierno
- National Center for Advancing Translational Sciences
- Grupo de la industria
- American Pistachio Growers
- Gobierno
- NCATS NIH HHS
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- National Institutes of Health (UM1TR004398)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-10-18 · J Nutr · vol. 155 · número 1 · págs. 168–174
- Editorial
- Elsevier BV
- Citado
- 5 citas · más que el 84% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 44 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Retinal Diseases and Treatments · Antioxidant Activity and Oxidative Stress · Nuts composition and effects
- Palabras clave
- macular pigment optical density, lutein, zeaxanthin, heterochromatic flicker photometry, eye health, dietary intervention, healthy older adults
- MeSH
- humans, pistacia, lutein, diet, single-blind method, adult, aged, middle aged, female, male, zeaxanthins, macular pigment
4 autores
- Tammy Maria Scott🇺🇸 · autor de correspondenciaTufts University
- Olaniyi Ogunbodede🇺🇸Tufts Medical Center
- Diane L. McKay🇺🇸Tufts University
- Elizabeth J. Johnson🇺🇸Tufts University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Pistachios are a bioavailable source of the xanthophyll lutein. Along with zeaxanthin, these plant pigments are major components of macular pigment (MP) in the human retina. MP can be non-invasively measured and is referred to as MP optical density (MPOD). MPOD is modifiable with dietary interventions that include lutein and zeaxanthin (L/Z). Higher MPOD protects the eye from light damage and is positively associated with eye health.
Objectives
This dietary intervention study aimed to evaluate the effect of pistachio consumption on MPOD.
Methods
This single-blinded, randomized controlled trial compared a 12-week pistachio intervention (2 oz/d) with usual diet (UD) on MPOD and serum L/Z in middle-aged to older healthy adults (n = 36) in a 1:1 randomization scheme. Participants were selected for habitually low L/Z intake and low baseline MPOD. MPOD was measured using heterochromatic flicker photometry at 4 retinal eccentricities during baseline, week 6, and week 12 study visits. Serum L/Z was analyzed using high-performance liquid chromatography. Primary statistical analysis was conducted on an intent-to-treat basis using repeated-measure analysis of variance.
Results
Compared with UD, MPOD of the participants in the pistachio intervention group (PIS) had significantly increased (P < 0.001) at all eccentricities over the initial 6-wk period. This increase was maintained at week 12. MPOD in the UD participants did not change during the 12-week period. Serum lutein concentration followed a similar pattern to MPOD; serum cis-lutein and zeaxanthin did not change in either group over the 12-wk intervention.
Conclusions
The results of our study demonstrate that a dietary intervention with pistachios is efficacious in increasing MPOD in healthy adults selected for habitually low intake of L/Z and low baseline MPOD. This suggests that pistachio consumption could be an effective dietary strategy for preserving eye health. Future studies need to evaluate the generalizability of our findings to other populations. This trial was registered at clinicaltrials.gov as NCT05283941.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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