The Effect of Repeated Low-Level Red-Light Therapy on Myopia Control and Choroid
Liu Y, Zhu M, Yan X, Li M, Xiang Y
Translational vision science & technology · 17 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (82000893); National Natural Science Foundation of China (81800821)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-10-21 · Transl Vis Sci Technol · vol. 13 · número 10 · pág. 29
- Editorial
- Association for Research in Vision and Ophthalmology
- Citado
- 20 citas · más que el 96% de estudios similares · 5.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 56 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Corneal surgery and disorders · Retinal Diseases and Treatments
- Palabras clave
- Choroid, Ophthalmology, Medicine, Light therapy, Optometry, Retina, Neuroscience, Biology, Internal medicine
- MeSH
- choroid, humans, myopia, tomography, optical coherence, refraction, ocular, treatment outcome, follow-up studies, adult, female, male, young adult, axial length, eye, low-level light therapy
5 autores
- Ying Liu🇨🇳Tongji Hospital; Huazhong University of Science and Technology
- Mengxia Zhu🇨🇳Tongji Hospital; Huazhong University of Science and Technology
- Xiaoqin Yan🇨🇳Tongji Hospital; Huazhong University of Science and Technology
- Mu Li🇨🇳 · autor de correspondenciaWuhan Union Hospital; Huazhong University of Science and Technology
- Yan Xiang🇨🇳Tongji Hospital; Huazhong University of Science and Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
To investigate the long-term effects of repeated low-level red light (RLRL) therapy on the axial length (AL), spherical equivalent (SE), and choroidal parameters.
Methods
Two hundred eight myopic eyes were recruited. The RLRL group included 100 eyes, whereas the control group included 108 eyes. Throughout the one-year follow-up period, changes in AL and SE were recorded for both groups. The RLRL group underwent additional choroidal imaging, and changes in choroidal thickness (CT), choroidal vascularity (CV), and choriocapillaris luminal area (CLA) were assessed before and after RLRL therapy.
Results
During the follow-up period, the changing trends in AL and SE differed significantly between the RLRL and control groups. In the RLRL group, AL decreased at three and six months (both P < 0.05) and returned to pretreatment values at 12 months (P = 0.453). In contrast, AL increased significantly throughout the follow-up period (three, six, and 12 months) in the control group (all P < 0.001). The SE increased significantly during the entire follow-up period in the RLRL group (all P < 0.001), whereas it decreased significantly in the control group (all P < 0.05). Regarding choroidal parameters, significant improvements were observed in CT, CV and CLA throughout the follow-up period (all P < 0.05), and changes in most choroidal parameters were significantly correlated with changes in AL and SE during the follow-up period (all P < 0.05). Furthermore, AL, SE, and most choroidal parameters showed significant correlations between changes at three and 12 months (all P < 0.05).
Conclusions
RLRL therapy significantly improved choroidal blood perfusion and circulation, which may explain the observed slowing or reversal of myopia progression in the RLRL group. Thus RLRL therapy may be a novel and effective method for controlling myopia. Furthermore, the short-term effect of photobiomodulation therapy (i.e., changes at three months) can be used to predict the long-term effects (i.e., changes at 12 months).
Translational relevance
In this study, RLRL therapy showed a significant control effect on the development of axial length and spherical equivalent. RLRL therapy also promoted the choroidal blood perfusion and circulation. RLRL therapy could be a novel and effective method for myopia control.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.