Effect of Time-Restricted Eating on Circulating Levels of IGF1 and Its Binding Proteins in Obesity: An Exploratory Analysis of a Randomized Controlled Trial
Akasheh RT, Ankireddy A, Gabel K, Ezpeleta M, Lin S, Tamatam CM, Reddy SP, Spring B, Cheng TD, Fontana L, Khan SA, Varady KA, Cienfuegos S, Kalam F
Nutrients · 7 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Breast Cancer Research Foundation
- Organización sin fines de lucro
- Australian Youth and Health Foundation
- Gobierno
- National Institutes of Health
- Gobierno
- Australian NHMRC Investigator
- Gobierno
- NIH HHS
- Subvenciones
- Breast Cancer Research Foundation (T32CA193193); Australian Youth and Health Foundation (APP1177797); Breast Cancer Research Foundation (R01DK119783); Breast Cancer Research Foundation (K12HD101373); Australian Youth and Health Foundation (T32CA193193); Australian Youth and Health Foundation (K12HD101373); Breast Cancer Research Foundation (APP1177797); National Institutes of Health (APP1177797); Australian Youth and Health Foundation (R01DK119783); National Institutes of Health (K12HD101373); National Institutes of Health (R01 DK119783); National Institutes of Health (T32CA193193)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-10-14 · Nutrients · vol. 16 · número 20 · pág. 3476
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 10 citas · más que el 89% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 38 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Growth Hormone and Insulin-like Growth Factors · Regulation of Appetite and Obesity
- Palabras clave
- time-restricted eating, insulin-like growth factor I, IGFBP-2, obesity, weight loss, insulin sensitivity, HOMA-IR, leptin, adipokines, 8-isoprostane, inflammation, high-sensitivity C-reactive protein, body composition, cardiovascular risk markers, diabetes risk, aging, cancer risk
- MeSH
- humans, insulin resistance, obesity, weight loss, insulin-like growth factor i, insulin-like growth factor binding proteins, insulin-like growth factor binding protein 1, insulin-like growth factor binding protein 2, insulin-like growth factor binding protein 3, fasting, body composition, time factors, adult, middle aged, female, male, adipokines, biomarkers
14 autores
- Rand T. Akasheh🇯🇴🇺🇸 · autor de correspondenciaAmerican University of Madaba; University of Illinois Chicago; The Ohio State University
- Aparna Ankireddy🇺🇸University of Illinois Chicago
- Kelsey Gabel🇺🇸University of Illinois Chicago
- Mark Ezpeleta🇺🇸University of Illinois Chicago
- Shuhao Lin🇺🇸University of Illinois Chicago
- Chandra Mohan Tamatam🇺🇸University of Illinois Chicago
- Sekhar P. Reddy🇺🇸University of Illinois Chicago
- Bonnie J. Spring🇺🇸Northwestern University
- Ting‐Yuan David Cheng🇺🇸The Ohio State University
- Luigi Fontana🇦🇺The University of Sydney; Royal Prince Alfred Hospital
- Seema Ahsan Khan🇺🇸Northwestern University
- Krista A Varady🇺🇸University of Illinois Chicago
- Sofia Cienfuegos🇺🇸University of Illinois Chicago
- Faiza Kalam🇺🇸Northwestern University; The Ohio State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Obesity is associated with alterations in circulating IGF1, IGF1-binding proteins (IGFBPs), insulin, inflammatory markers, and hormones implicated in cardiovascular disease, diabetes, cancer, and aging. However, the effects of 4 and 6 h time-restricted eating (TRE) on circulating IGF1 and IGFBPs is uncertain.
Objective
This study aimed to investigate the effects of TRE on plasma IGF1, IGFBP1, IGFBP2, and IGFBP3, and whether these effects were mediated by weight loss or body composition changes. Insulin sensitivity, glucose control, adipokines, and inflammatory markers were also examined.
Design
An exploratory analysis of an 8-week randomized controlled trial implementing a daily TRE intervention was carried out.
Participants/setting
This study was conducted at the University of Illinois at Chicago in 2019. Participants with obesity were randomized to 4 or 6 h TRE (n = 35) or a control (n = 14) group. Plasma biomarkers were measured by ELISA at baseline and week 8. In a sub-analysis, participants were stratified into higher- (>3.5%) and lower- (≤3.5%) weight-loss groups.
Intervention
Participants fasted daily from 7 p.m. to 3 p.m. in the 4 h TRE group (20 h) and from 7 p.m. to 1 p.m. in the 6 h TRE group (18 h), followed by ad libitum eating for the remainder of the day. Controls received no dietary recommendations.
Main outcome measures
IGF1, IGFBPs, hsCRP, and adipokines were the main outcome measures of this analysis.
Statistical analysis
Repeated measures ANOVA and mediation analysis were conducted.
Results
Body weight significantly decreased with TRE (-3.6 ± 0.3%), contrasting with controls (+0.2 ± 0.5%, p < 0.001). Significant effects of TRE over time were observed on plasma IGFBP2, insulin, HOMA-IR, and 8-isoprostane levels, without affecting other biomarkers. In the sub-analysis, IGFBP2 increased while leptin and 8-isoprostane decreased significantly only in the "higher weight loss" subgroup. Changes in insulin and HOMA-IR were related to TRE adherence.
Conclusions
Eight-week daily 4 to 6 h TRE did not affect IGF1, IGFBP1, or IGFBP3 levels but improved insulin, HOMA-IR, and 8-isoprostane. IGFBP2 increased and leptin decreased when weight loss exceeded 3.5% of baseline.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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