Alzheimer's Disease May Benefit from Olive Oil Polyphenols: A Systematic Review on Preclinical Evidence Supporting the Effect of Oleocanthal on Amyloid-β Load
Zupo R, Castellana F, Panza F, Solfrizzi V, Lozupone M, Tardugno R, Cicero N, Corbo F, Crupi P, Sardone R, Clodoveo ML
Current neuropharmacology · 10 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ministero della Salute
- Gobierno
- Ministry of Health
- Subvenciones
- Ministero della Salute (PNRR-MAD-2022- 12376656)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-11-01 · Curr Neuropharmacol · vol. 23 · número 10 · págs. 1249–1259
- Editorial
- Bentham Science Publishers
- Citado
- 12 citas · más que el 71% de estudios similares · 0.9× el promedio de su campo
- Referencias
- 46 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY
- Áreas de investigación
- Alzheimer's disease research and treatments · Medicinal Plants and Neuroprotection · Dementia and Cognitive Impairment Research
- Palabras clave
- Alzheimer's disease, oleocanthal, extra virgin olive oil, amyloid-beta, Mediterranean diet, polyphenols, preclinical models, 5xFAD mice, hippocampus, neuroprotection, anti-inflammatory activity, dietary supplementation
- MeSH
- animals, humans, mice, alzheimer disease, disease models, animal, aldehydes, phenols, diet, mediterranean, amyloid beta-peptides, polyphenols, olive oil, cyclopentane monoterpenes
11 autores
- Roberta Zupo🇮🇹 · autor de correspondenciaUniversity of Bari Aldo Moro
- Fabio Castellana🇮🇹University of Bari Aldo Moro
- Francesco Panza🇮🇹University of Bari Aldo Moro
- Vincenzo Solfrizzi🇮🇹University of Bari Aldo Moro
- Madia Lozupone🇮🇹University of Bari Aldo Moro
- Roberta Tardugno🇮🇹University of Bari Aldo Moro
- Nicola Cicero🇮🇹University of Messina
- Filomena Corbo🇮🇹University of Bari Aldo Moro
- Pasquale Crupi🇮🇹University of Palermo
- Rodolfo Sardone🇬🇧University of Liverpool
- Maria Lisa Clodoveo🇮🇹University of Bari Aldo Moro
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Mediterranean diet may enhance cognitive function and delay the progression of Alzheimer's disease (AD). We conducted a systematic review to investigate the effect of oleocanthal (OC) from extra-virgin olive oil (EVOO) on amyloid-β (Aβ) burden in preclinical models of AD, considering the anti-inflammatory and neuroprotective effects of EVOO biophenols, which are key components of the Mediterranean dietary model.
Methods
The literature was searched through six electronic databases until February 2023. Screening of 52 retrieved articles for inclusion criteria resulted in 7 preclinical reports evaluating the effect of an OC-supplemented diet on AD trajectories by means of Aβ load or clearance in affected models. Reports were appraised for risk of bias using the SYRCLE's RoB tool. A protocol was registered on PROSPERO.
Results
Case control prevailed over the case-crossover design, and the geographical distribution was uniformly American. The study population mostly included 5xFAD, otherwise TgSwDI or wild-type C57BL/6 mouse models. We found a role of OC in reducing Aβ load in the hippocampal parenchyma and microvessels compared with controls. An increased cerebral clearance of Aβ through the bloodbrain barrier and a substantial improvement in metabolic and behavioral parameters were also reported in preclinical models under an OC-enriched diet. The risk of bias was shown to be moderate overall.
Conclusion
Preclinical data are promising about the effects of OC from the Mediterranean diet's EVOO in relieving the burden of Aβ in AD; however, further evidence is needed to corroborate the efficacy of this biophenol and strengthen the speculated causal pathway.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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