Financiado en parte por Ixoreal BioMed Inc
Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study
Kale S, Lopresti A, Suri R, Garg N, Langade D
Journal of psychoactive drugs · 5 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Ixoreal BioMed Inc
Según 1 financiador declarado.
Publicación
- Publicado
- 2024-11-05 · J Psychoactive Drugs · vol. 58 · número 1 · págs. 45–57
- Editorial
- Taylor & Francis
- Citado
- 9 citas · más que el 94% de estudios similares · 4.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Complementary and Alternative Medicine Studies · Medicinal Plants and Neuroprotection
- Palabras clave
- Mood, Cognition, Placebo, Randomized controlled trial, Medicine, Root (linguistics), Clinical psychology, Psychology, Psychiatry, Physical therapy, Alternative medicine, Internal medicine
- MeSH
- humans, plant roots, plant extracts, treatment outcome, phytotherapy, prospective studies, double-blind method, mental fatigue, affect, cognition, cognition disorders, mood disorders, adult, aged, middle aged, female, male, executive function
5 autores
- Sanjiv S. Kale🇮🇳D.Y. Patil University
- Adrian L. Lopresti🇺🇸Clinical Research Management
- Ravleen K Suri🇮🇳 · autor de correspondenciaD.Y. Patil University
- Neha Garg🇮🇳D.Y. Patil University
- Deepak Langade🇮🇳D.Y. Patil University
Resumen
El texto original del estudio, en el idioma en que se publicó.
This prospective, randomized, placebo-controlled study assessed the effects of Ashwagandha root extract (ARE) on cognition, energy, and mood in adults with self-reported cognitive and energy problems. Healthy subjects aged 30-75 years were randomized to receive ashwagandha (Withania somnifera) root extract (ARE) 600 mg/day (n = 60)/identical placebo (n = 60) orally for 8 weeks. Cognitive function was assessed at baseline and week 8 using a Computerized Mental Performance Assessment System (COMPASS). Secondary outcomes were Profile of Mood States Abbreviated Version (POMS-A), Mental Fatigue Scale (MFS) and Behavior Rating Inventory of Executive Function-Adult (BRIEF-A) for effects on mood, mental fatigue and executive function, respectively, assessed at baseline, week 4 and 8. Greater improvement (p < .05) from baseline scores were seen with ARE as against placebo for COMPASS items episodic memory, working memory and accuracy of attention. ARE also improved the POMS-A, MFS and BRIEF-A scores from baseline suggesting an improvement in mood, vigor, and an increase in the executive functioning respectively with ARE. The herb was well tolerated and had a good patient compliance with no serious adverse events reported in either of the groups. This study suggests that a dose of 600 mg a day can improve cognition, energy, and mood in adults with self-reported cognitive and energy problems.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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