Safety of and chorioretinal circulation during repeated low-level red-light therapy for myopic children
Jiang Z, Chen S, Wang R, Ma J
Clinical & experimental ophthalmology · 8 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Natural Science Foundation of Guangdong Province
- Gobierno
- National Key Research and Development Program of China
- Gobierno
- Guangdong Natural Science Foundation
- Subvenciones
- National Key Research and Development Program of China (2023YFC2506100); Natural Science Foundation of Guangdong Province (2023A1515012470)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2024-11-05 · Clin Exp Ophthalmol · vol. 53 · número 2 · págs. 119–132
- Editorial
- Wiley
- Citado
- 11 citas · más que el 95% de estudios similares · 4.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 26 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Retinal Diseases and Treatments · Laser Applications in Dentistry and Medicine · Retinopathy of Prematurity Studies
- Palabras clave
- Medicine, Microperimetry, Ophthalmology, Retinal, Refractive error, Emmetropia, Fundus (uterus), Visual acuity
- MeSH
- microcirculation, retinal vessels, choroid, humans, myopia, tomography, optical coherence, fluorescein angiography, electroretinography, phototherapy, single-blind method, eyeglasses, regional blood flow, visual acuity, adolescent, child, female, male, axial length, eye
4 autores
- Zhaoxin Jiang🇨🇳Sun Yat-sen University
- Shuyu Chen🇨🇳Sun Yat-sen University
- Renchun Wang🇨🇳Sun Yat-sen University
- Jin Ma🇨🇳 · autor de correspondenciaSun Yat-sen University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
To evaluate the safety of repeated low-level red-light (RLRL) therapy in children, and the dynamic evolution of choroidal and retinal blood flow.
Methods
This is a single-centre, randomised, single-blind, parallel-group clinical trial. Seventy myopic children were randomly assigned to either the intervention group [receiving RLRL therapy plus single-vision spectacle (SVS)] or the control group (wearing SVS). Participants underwent comprehensive ophthalmic examinations following their first irradiation, 9 months continuous RLRL therapy and stop of treatment. Quantitative analyses of choroidal and retinal microcirculation were analysed via optical coherence tomography angiography.
Results
Over 9 months of treatment, while the RLRL treatment demonstrated significantly less increases in refractive error and axial length compared with the SVS treatment (ps 0.05). A single red-light exposure did not exert a significant influence on choroidal thickness (ps > 0.05). Upon continuous treatment, the RLRL group achieved peak values in these circulations at 9 months (ps 0.05). As the frequency of red-light exposures intensified, there was a consistent surge in these circulations (ps < 0.05).
Conclusions
Nine months of continuous RLRL exposure does not cause toxic side effects on retinal or optic nerve functions, and there is a time-dependent cumulative response in choroidal and retinal circulation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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