Longer-term effects of intermittent fasting on body composition and cardiometabolic health in adults with overweight and obesity: A systematic review and meta-analysis
Khalafi M, Maleki AH, Ehsanifar M, Symonds ME, Rosenkranz SK
Obesity reviews : an official journal of the International Association for the Study of Obesity · 28 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2024-11-05 · Obes Rev · vol. 26 · número 2 · pág. e13855
- Editorial
- Wiley
- Citado
- 33 citas · más que el 91% de estudios similares · 2.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 101 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Nutritional Studies and Diet
- Palabras clave
- intermittent fasting, obesity, overweight, body composition, cardiometabolic health, fat mass, fat-free mass, visceral fat, waist circumference, fasting blood glucose, triglycerides, blood pressure, HDL cholesterol, weight loss
- MeSH
- humans, cardiovascular diseases, obesity, weight loss, caloric restriction, fasting, body composition, adult, overweight, randomized controlled trials as topic, intermittent fasting
5 autores
- Mousa Khalafi🇮🇷 · autor de correspondenciaUniversity of Kashan
- Aref Habibi Maleki🇮🇷Urmia University
- Mahsa Ehsanifar🇮🇷Urmia University
- Michael Edward Symonds🇬🇧University of Nottingham
- Sara K. Rosenkranz🇺🇸University of Nevada, Las Vegas
Resumen
El texto original del estudio, en el idioma en que se publicó.
The aim of the present study was to investigate the effects of long-term intermittent fasting (IF) on body composition and cardiometabolic health in adults with overweight and obesity. PubMed, Web of Science, and Scopus were searched from inception to March 2024 to identify original randomized trials that investigated the effects of IF versus either a control diet (CON) and/or continuous caloric restriction (CR). Participants were adults with overweight and obesity and intervention durations were ≥ 6 months. Overall, a total of 24 studies involving 2032 participants were included in the meta-analysis. Compared with CON, IF significantly reduced body weight [WMD: -2.84 kg], BMI [WMD: -1.41 kg.m2], fat mass [WMD: -3.06 kg], fat-free mass [WMD: -0.81 kg], waist circumference [WMD: -3.85 cm], visceral fat [SMD: -0.37], fasting glucose [WMD: -0.14 mmol/l], triglycerides [WMD: -0.12 mmol/l], and diastolic blood pressure [WMD: -2.24 mmHg]. Conversely, IF significantly increased high-density lipoproteins [WMD: 0.04 mmol/l] when compared with CON, but had no effects on insulin, hemoglobin A1c%, total cholesterol, low-density lipoprotein, or systolic blood pressure. Compared with CR, IF significantly reduced fat mass [WMD: -0.70 kg], body fat percentage [WMD: -0.59%], and DBP [WMD: -0.91 mmHg], and increased HDL [WMD: 0.03 mmol/l], with no other significant effects. Subgroup analyses showed that the mode of IF and intervention duration were the primary moderators of IF effects on the markers. In adults with overweight or obesity, IF and CR are comparably effective for reducing body weight and adiposity, as well as for improving cardiometabolic health markers.
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