Comparison of n-3 PUFA-Enriched vs. Olive-Oil-Based Lipid Emulsion on Oxidative Stress and Inflammatory Response in Critically Ill Post-Surgery Adults: Secondary Analysis of a Randomized Controlled Trial
Cuartero-Corbalán N, Martínez-Lozano Aranaga F, Gómez-Ramos MJ, Gómez-Sánchez MB, Avilés-Plaza FV, Núñez-Sánchez MA, Morillas-Ruiz JM
International journal of molecular sciences · 3 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Instituto de Salud Carlos III
- Gobierno
- European Regional Development Fund
- Subvenciones
- Instituto de Salud Carlos III (CP23/00051); Instituto de Salud Carlos III (PI13/01551)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-10-31 · Int J Mol Sci · vol. 25 · número 21 · pág. 11739
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 3 citas · más que el 70% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 43 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Clinical Nutrition and Gastroenterology · Fatty Acid Research and Health · Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Palabras clave
- intravenous lipid emulsion, omega-3 fatty acids, olive oil, parenteral nutrition, oxidative stress, inflammation, critically ill patients, postoperative patients, malnutrition, 8-isoprostane, total antioxidant capacity, IL-1β, interleukin-6, abdominal surgery
- MeSH
- humans, critical illness, inflammation, fatty acids, omega-3, soybean oil, fat emulsions, intravenous, fish oils, antioxidants, parenteral nutrition, oxidative stress, adult, aged, middle aged, female, male, biomarkers, olive oil
7 autores
- Nerea Cuartero🇪🇸Universidad Católica de Murcia
- Fátima Martínez-Lozano Aranaga🇪🇸Hospital Reina Sofía de Murcia
- María Jesús Gómez-Ramos🇪🇸Hospital Reina Sofía de Murcia
- María B. Gómez‐Sánchez🇪🇸Hospital Reina Sofía de Murcia
- Francisco V. Avilés-Plaza🇪🇸Hospital Universitario Virgen de la Arrixaca
- María Ángeles Núñez‐Sánchez🇪🇸 · autor de correspondenciaInstituto Murciano de Investigación Biosanitaria
- Juana María Morillas-Ruiz🇪🇸Universidad Católica de Murcia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Malnutrition in critically ill patients represents a major concern as it can lead to adverse outcomes including increased morbidity and mortality. These patients exhibit an impaired immune response accompanied by increased oxidative stress. Nutritional support, including parenteral nutrition (PN), is critical in these patients. Intravenous lipid emulsions (ILEs), a key component of PN, provide energy and intervene in the modulation of inflammation. This was a secondary study of a randomized clinical trial at the Reina Sofia University Hospital (Murcia, Spain) for critically ill patients following major abdominal surgery that were administered PN supplemented with olive-oil-based ILE (OO-ILE, n = 29) or a mixed-lipid ILE (soybean oil, medium chain triglycerides, OO and fish oil, SMOF-ILE, n = 25). The effects on clinical outcomes, metabolic markers, oxidative stress, and inflammation were evaluated. No significant differences were observed between groups in the clinical parameters and outcomes, oxidative stress, or inflammatory markers. The within-group evaluation demonstrated an increase in total antioxidant capacity in both groups, while OO-ILE increased the levels of 15-F2t-isoprostane. In addition, the results showed that both mixtures reduced the release of IL-1β and IL-6. These findings suggest that both treatments had similar effects on oxidative stress and inflammatory response in this type of patient.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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