Effects of different types of intermittent fasting on metabolic outcomes: an umbrella review and network meta-analysis
Chen YE, Tsai HL, Tu YK, Chen LW
BMC medicine · 22 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- National Taiwan University
- Gobierno
- National Science and Technology Council
- Subvenciones
- National Taiwan University (110L881002); National Taiwan University (111L7306); National Taiwan University (110L7418); National Taiwan University (111L7304)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2024-11-12 · BMC Med · vol. 22 · número 1 · pág. 529
- Editorial
- BioMed Central
- Citado
- 32 citas · más que el 98% de estudios similares · 7.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 136 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Nutritional Studies and Diet
- Palabras clave
- intermittent fasting, time-restricted eating, alternate-day fasting, 5:2 diet, continuous energy restriction, metabolic health, weight loss, dietary intervention
- MeSH
- humans, fasting, randomized controlled trials as topic, intermittent fasting
4 autores
- Yu-En Chen🇹🇼National Taiwan University
- Hui-Li Tsai🇹🇼National Taiwan University
- Yu‐Kang Tu🇹🇼National Taiwan University
- Ling‐Wei Chen🇹🇼 · autor de correspondenciaNational Taiwan University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Intermittent fasting (IF) holds promise for enhancing metabolic health. However, the optimum IF forms and their superiority over continuous energy restriction (CER) remain unclear due to disconnected findings.
Methods
We systematically searched PubMed, Embase, and the Cochrane databases for meta-analyses of randomized controlled trials (RCTs) investigating the association between IF and metabolic health outcomes. Subsequently, we performed an umbrella review and network meta-analysis (NMA) to evaluate the efficacy of different forms of IF (time-restricted eating (TRE), alternate-day fasting (ADF), and 5:2 diet (regular eating for 5 days and energy restriction for 2 days per week)) compared to CER and usual diets on metabolic health outcomes. To assess the certainty of both direct and indirect estimates, we employed the Confidence in Network Meta-Analysis (CINeMA) approach. Additionally, we calculated the surface under the cumulative ranking curve (SUCRA) for each dietary strategy to determine their ranking in terms of metabolic health benefits.
Results
Ten of the best and non-redundant meta-analysis studies, involving 153 original studies and 9846 participants, were included. When considering direct evidence only, all IF forms significantly reduced body weight compared to usual diets. In NMA incorporating indirect evidence, all IF regimens also significantly reduced body weight compared to usual diets. In the SUCRA of NMA, IF ranked higher than usual diets or CER in 85.4% and 56.1% of the outcomes, respectively. ADF had the highest overall ranking for improving metabolic health (ranked first: 64.3%, ranked second: 14.3%).
Conclusions
Overall, all IF forms demonstrate potentials to improve metabolic health, with ADF appearing to produce better outcomes across investigated outcomes. Further high-quality trials are warranted to confirm the (relative) efficacy of IF on metabolic health.
Trial registration
PROSPERO (record no: CRD42022302690).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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