Effects of long-term almond consumption on markers for vascular function and cardiometabolic risk in men and women with prediabetes: results of a randomized, controlled cross-over trial
Chavez-Alfaro MA, Mensink RP, Gravesteijn E, Joris PJ, Plat J
European journal of nutrition · 4 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- NUTRIM School of Nutrition and Translational Research in Metabolism
Según 1 financiador declarado.
Publicación
- Publicado
- 2024-11-15 · Eur J Nutr · vol. 64 · número 1 · pág. 7
- Editorial
- Springer Science+Business Media
- Citado
- 7 citas · más que el 82% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 67 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nuts composition and effects · Cardiovascular Health and Disease Prevention · Nutritional Studies and Diet
- Palabras clave
- almond consumption, prediabetes, overweight and obesity, arterial stiffness, pulse wave velocity, retinal microvasculature, endothelial dysfunction, inflammation, blood pressure variability, ambulatory blood pressure, cardiometabolic risk, soluble adhesion molecules, C-reactive protein, dietary intervention, men and women comparison, sex differences, 24-hour ambulatory blood pressure, systolic blood pressure
- MeSH
- endothelium, vascular, humans, cardiovascular diseases, prediabetic state, vascular cell adhesion molecule-1, diet, cross-over studies, single-blind method, blood pressure, adult, middle aged, female, male, vascular stiffness, pulse wave analysis, biomarkers, prunus dulcis, cardiometabolic risk factors
5 autores
- Marco A Chavez-Alfaro🇳🇱Maastricht University
- Ronald P. Mensink🇳🇱Maastricht University
- Elske Gravesteijn🇳🇱Maastricht University
- Peter J. Joris🇳🇱Maastricht University
- Jogchum Plat🇳🇱 · autor de correspondenciaMaastricht University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
The aim of this study was to investigate the long-term effects of almond consumption on peripheral vascular function, ambulant blood pressure profiles (ABP), and serum/plasma markers reflecting endothelial dysfunction and inflammation in participants with overweight/obesity and prediabetes.
Methods
Thirty-four participants completed this single-blinded, randomized, cross-over trial with 5-month intervention and control periods, separated by a 2-month wash-out. During the intervention period, participants consumed 50 g of whole almonds daily. At the end of each intervention period, peripheral vascular function was assessed by measuring the carotid-to-femoral and carotid-to-radial pulse wave velocities (PWVc-f and PWVc-r, respectively) and retinal microvascular calibers. Serum/plasma concentrations of soluble intracellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), interleukin-6 (IL-6), IL-8, tumor necrosis factor-alpha (TNFα), serum amyloid A protein (SAA) and high-sensitivity C-reactive protein (hs-CRP) and 24-hour ABP were also analyzed.
Results
Almond consumption did not significantly affect arterial stiffness (PWVc-f and PWVc-r), while central retinal venular equivalent (CRVE) was minimally increased by 2 μm (P = 0.019). Central retinal arteriolar equivalent (CRAE), the arteriolar-to-venular ratio (AVR), and endothelial and inflammatory serum/plasma markers showed no significant changes after almond consumption. Almond consumption reduced systolic blood pressure (SBP; -3 mmHg 24-hour P = 0.035, -4 mmHg daytime P = 0.046, and - 4 mmHg during nighttime P = 0.029), SBP variability during 24-hour, daytime, and nighttime (P = 0.005, P = 0.019, and P = 0.003, respectively), and diastolic blood pressure variability during nighttime (P ≤ 0.001).
Conclusion
Almond consumption did not affect arterial stiffness, retinal microvasculature calibers, or serum and plasma markers for endothelial dysfunction and inflammation in participants with prediabetics, while BP and BP variability were improved.
Clinical trial registration
This clinical trial was registered in February 2018 as NCT03419702.
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