Supplementation of Olive Oil and Flaxseed Oil on Blood Pressure and Inflammation in Healthy and At-Risk Adults: A Systematic Literature Review and Meta-Analysis
McNabb TB, Young I, Newman RG, Skinner RC, Benedito VA, Tou JC
Current hypertension reviews · 2 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-11-19 · Curr Hypertens Rev · vol. 20 · número 3 · págs. 141–155
- Editorial
- Bentham Science Publishers
- Citado
- 4 citas · más que el 51% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 54 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Blood Pressure and Hypertension Studies
- Palabras clave
- olive oil supplementation, blood pressure, hypertension, inflammation, C-reactive protein, interleukin-6, TNF-α, omega-3 fatty acids, omega-9 fatty acids, dietary supplementation, endothelial function, prehypertension, healthy adults, at-risk adults, systolic blood pressure, diastolic blood pressure, risk of bias
- MeSH
- humans, hypertension, inflammation, linseed oil, inflammation mediators, treatment outcome, blood pressure, dietary supplements, adult, randomized controlled trials as topic, biomarkers, olive oil
6 autores
- Tara Bess McNabb🇺🇸West Virginia University
- Ian Young🇨🇦Toronto Metropolitan University
- Rachel G. Newman🇺🇸University of Chicago
- Roy Chris Skinner🇺🇸University of Vermont
- Vagner Augusto Benedito🇺🇸West Virginia University
- Janet C. L. Tou🇺🇸 · autor de correspondenciaWest Virginia University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Adding olive oil (OO) and flaxseed oil (FLO) to the diet has been reported to improve endothelial function and reduce inflammation. However, the efficacy of supplementing OO and FLO on blood pressure (BP) in normo-, pre-, and hypertensive stage 1 adults is uncertain.
Objective
This study aimed to systematically review the literature on OO and FLO supplementation on BP and select inflammatory markers in healthy adults and adults at risk of hypertension.
Methods
Four databases, PubMed, CINHAL, Web of Science, and Medline (Ovid), were searched from inception until October 2023 for randomized control trials (RCTs) comparing OO and FLO supplementation in normotensive or adults at risk of hypertension. The outcomes included were systolic blood pressure (SBP) and/or diastolic blood pressure (DBP) and at least one inflammatory marker, C-reactive protein (CRP), interleukin6 (IL6), or tumor necrosis factor alpha (TNFα). The risk of bias was assessed using version 2 of the Cochrane risk of bias tool for RCTs, publication bias visualization was performed using funnel plots, and meta-analysis was completed to generate average estimates of effects in 2024.
Results
Seventeen RCTs, comprising 14 studies on OO and 3 on FLO, met the inclusion criteria. Meta-analysis using a random-effects model reported no significant effect on SBP n=17 mean difference (MD) -0.48; 95% CI: -1.76, 0.80; p=0.65, I2 =0%) and DBP (n=16, MD -0.47; 95% CI: -1.33, 0.39; p=0.65, I2 =0%) or inflammatory markers, CRP (n=8, MD 0.11; 95% CI: -1.18, 0.40; p=0.98, I2 =0%), IL6 (n=3, MD -0.15; 95% CI: -0.57, 0.27; p=0.87, I2 =0%), and TNFα (n=3, MD-0.08; 95% CI: -0.12, -0.03; p=0.98, I2 =0%).
Conclusion
Longer-duration, higher-dose, and larger-scale RCTs are needed to better understand the efficacy of OO and FLO supplementation on BP. Further insight will better inform dietary supplement use for preventing hypertension.
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