Time-restricted eating reveals a "younger" immune system and reshapes the intestinal microbiome in human
Chen Y, Li X, Yang M, Jia C, He Z, Zhou S, Ruan P, Wang Y, Tang C, Pan W, Long H, Zhao M, Lu L, Peng W, Akbar A, Wu IX, Li S, Wu H, Lu Q
Redox biology · 29 citas
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Cómo se estudió
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- Ensayo clínico controlado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Ministry of Science and Technology of the People's Republic of China
- Universidad u hospital
- Chinese Academy of Meteorological Sciences
- Gobierno
- Natural Science Foundation of Hunan Province
- Universidad u hospital
- Chinese Academy of Medical Sciences
- Gobierno
- National Key Research and Development Program of China
- Universidad u hospital
- Chinese Academy of Medical Sciences & Peking Union Medical College
- Gobierno
- Natural Science Foundation of Hunan Province
- Gobierno
- Ministry of Science and Technology of the People's Republic of China
- Subvenciones
- National Natural Science Foundation of China (82273540); National Natural Science Foundation of China (82373488); National Natural Science Foundation of China (32141004); National Key Research and Development Program of China (2022YFC3601800); Natural Science Foundation of Hunan Province (2024JJ4077); Chinese Academy of Medical Sciences (2021-I2M-1-059); Chinese Academy of Medical Sciences (2021-RC320-001); National Natural Science Foundation of China (82173425); National Natural Science Foundation of China (82473530)
Según 9 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-11-09 · Redox Biol · vol. 78 · pág. 103422
- Editorial
- Elsevier BV
- Citado
- 32 citas · más que el 98% de estudios similares · 7.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 83 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Dietary Effects on Health · Circadian rhythm and melatonin · Diet and metabolism studies
- Palabras clave
- Immunosenescence, Immune system, Microbiome, Calorie, Gut microbiome, Biology, Physiology, Immunology, Medicine, Gerontology, Bioinformatics, Endocrinology
- MeSH
- cd4-positive t-lymphocytes, immune system, humans, adult, middle aged, female, male, gastrointestinal microbiome
19 autores
- Yiran Chen🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Chinese Academy of Medical Sciences Dermatology Hospital
- Xi Li🇨🇳Central South University; Second Xiangya Hospital of Central South University
- Ming Yang🇨🇳Central South University; Second Xiangya Hospital of Central South University
- Jia Chen🇨🇳Central South University; Second Xiangya Hospital of Central South University
- Zhenghao He🇨🇳Central South University; Second Xiangya Hospital of Central South University
- Suqing Zhou🇨🇳Central South University; Second Xiangya Hospital of Central South University
- Pinglang Ruan🇨🇳Central South University; Second Xiangya Hospital of Central South University
- Yikun Wang🇨🇳Central South University; Second Xiangya Hospital of Central South University
- Congli Tang
- Wenjing Pan🇨🇳Hunan University of Technology
- Hai Long🇨🇳Central South University; Second Xiangya Hospital of Central South University
- Ming Zhao🇨🇳Central South University; Chinese Academy of Medical Sciences & Peking Union Medical College; Second Xiangya Hospital of Central South University
- Liwei Lu🇨🇳🇫🇷🇭🇰City University of Hong Kong, Shenzhen Research Institute; Institut de Recherche et d’Innovation; University of Hong Kong
- Weijun Peng🇨🇳Central South University; Second Xiangya Hospital of Central South University
- Arne N. Akbar🇬🇧University College London
- I-Chen Wu🇨🇳Central South University
- Song Li🇨🇳Hunan Provincial Maternal and Child Health Hospital; University of South China
- Haijing Wu🇨🇳Central South University; Second Xiangya Hospital of Central South University
- Qianjin Lu🇨🇳Central South University; Chinese Academy of Medical Sciences & Peking Union Medical College; Chinese Academy of Medical Sciences Dermatology Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Time-restricted eating (TRE) has been shown to extent lifespans in drosophila and mouse models by affecting metabolic and anti-inflammatory activities. However, the effect of TRE on the human immune system, especially on immunosenescence, intestinal microbiome, and metabolism remains unclear. We conducted a 30-day 16:8 TRE single-arm clinical trial with 49 participants. Participants consumed daily meals from 9 a.m. to 5 p.m., provided by a nutrition canteen with a balanced, calorie-appropriate nutrition, which is designed by clinical nutritionists (ChiCTR2200058137). We monitored weight changes and weight-related parameters and focused on changes in the frequency of CD4+ senescent T cells, immune repertoire from peripheral blood, as well as serum metabolites and gut microbiota. We found that up to 95.9 % of subjects experienced sustained weight loss after TRE. The frequency of circulating senescent CD4+ T cells was decreased, while the frequency of Th1, Treg, Tfh-like, and B cells was increased. Regarding the immune repertoire, the proportions of T cell receptor alpha and beta chains were increased, whereas B cell receptor kappa and lambda chains were reduced. In addition, a reduced class switch recombination from immunoglobulin M (IgM) to immunoglobulin A (IgA) was observed. TRE upregulated the levels of anti-inflammatory and anti-aging serum metabolites named sphingosine-1-phosphate and prostaglandin-1. Additionally, several anti-inflammatory bacteria and probiotics were increased, such as Akkermansia and Rikenellaceae, and the composition of the gut microbiota tended to be "younger". Overall, TRE showed multiple anti-aging effects, which may help humans maintain a healthy lifestyle to stay "young". Clinical Trial Registration URL: https://www.chictr.org.cn/showproj.html?proj=159876.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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