Cardiac Rehabilitation for Prediabetes and Metabolic Syndrome Remission: Impact of Ultraprocessed Food-Intake Reduction and Time-Restricted Eating in the DIABEPIC-1 Study
Iglesies-Grau J, Dionne V, Latour É, Gayda M, Besnier F, Gagnon D, Debray A, Gagnon C, Tessier AJ, Paradis A, Klai C, Martin N, Pelletier V, Simard F, Nigam A, L'Allier PL, Juneau M, Bouabdallaoui N, Bherer L
CJC open · 5 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Université de Montréal
- Universidad u hospital
- Institut de Cardiologie de Montréal
- Subvenciones
- Institut de Cardiologie de Montréal (2022-3005)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-08-09 · CJC Open · vol. 6 · número 11 · págs. 1411–1421
- Editorial
- Elsevier BV
- Citado
- 6 citas · más que el 81% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- Prediabetes, Medicine, Metabolic syndrome, Rehabilitation, Food intake, Reduction (mathematics), Internal medicine, Cardiology, Endocrinology, Diabetes mellitus, Physical therapy, Obesity, Type 2 diabetes
19 autores
- Josep Iglésies🇨🇦 · autor de correspondenciaMontreal Heart Institute; Université de Montréal
- Valérie Dionne🇨🇦Montreal Heart Institute; Université de Montréal
- Élise Latour🇨🇦Montreal Heart Institute
- Mathieu Gayda🇨🇦Montreal Heart Institute; Université de Montréal
- Florent Besnier🇨🇦Montreal Heart Institute; Université de Montréal
- Daniel Gagnon🇨🇦Montreal Heart Institute; Université de Montréal
- Amélie Debray🇨🇦Montreal Heart Institute; Université de Montréal
- Christine Gagnon🇨🇦Montreal Heart Institute
- Anne‐Julie Tessier🇨🇦Montreal Heart Institute
- Andréanne Paradis🇨🇦Montreal Heart Institute
- Chiheb Klai🇨🇦Montreal Heart Institute
- Nicolas Martin🇨🇦Montreal Heart Institute
- Veronique Anne Pelletier🇨🇦Montreal Heart Institute
- François Simard🇨🇦Montreal Heart Institute; Université de Montréal
- Anil Nigam🇨🇦Montreal Heart Institute; Université de Montréal
- Philippe L. L’Allier🇨🇦Montreal Heart Institute; Université de Montréal
- Martin Juneau🇨🇦Montreal Heart Institute; Université de Montréal
- Nadia Bouabdallaoui🇨🇦Montreal Heart Institute; Université de Montréal
- Louis Bherer🇨🇦Montreal Heart Institute; Institut Universitaire de Gériatrie de Montréal; Université de Montréal
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Cardiac rehabilitation programs provide a valuable opportunity to promote the adoption of healthy lifestyle behaviors in patients with atherosclerotic cardiovascular diseases (ASCVDs) and metabolic comorbidities, including metabolic syndrome and prediabetes. However, strategies to reverse these conditions remain to be explored. The DIABEPIC-1 study aimed to assess the feasibility of an enhanced 6-month cardiac rehabilitation program for patients with ASCVD while investigating prediabetes and metabolic syndrome remission.
Methods
The study combined exercise training with a comprehensive nutritional intervention, emphasizing reduction in intake of ultraprocessed foods, adoption of a Mediterranean diet, and implementation of time-restricted eating. Baseline, 3-month, and 6-month assessments included segmental body-composition measurements, blood analysis, maximal exercise testing, nutritional diaries recorded with the Keenoa AI app, and lifestyle questionnaires. Remission criteria included a return to an HbA1c level of < 5.7%, and < 3 National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP-III) criteria for prediabetes and metabolic syndrome, respectively.
Results
A total of 36 participants were recruited. The study demonstrated completion rates of 94.4% at 3 months, and 88.9% at 6 months, and a mean compliance rate of 92.5% for planned clinical appointments. Significant reductions in waist circumference (-9.2 cm, P P < 0.001) were observed. Improvement in glycemic and lipid profiles, insulin-resistance marker levels, and liver health were noted. Participants enhanced their cardiorespiratory fitness, reduced their consumption of ultraprocessed food, and increased their adherence to the Mediterranean diet and time-restricted eating. Notably, 50% achieved prediabetes remission, and 70% with metabolic syndrome at baseline achieved remission.
Conclusions
The study demonstrates the possibility of enhancing cardiac rehabilitation with an intensive nutritional intervention, yielding clinically significant outcomes, including remission of key risk factors in a substantial number of ASCVD patients.
Clinical trial registration
ClinicalTrials.gov, NCT05459987.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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