Impact of daily fasting duration on body composition and cardiometabolic risk factors during a time-restricted eating protocol: a randomized controlled trial
Sampieri A, Paoli A, Spinello G, Santinello E, Moro T
Journal of translational medicine · 15 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- European Commission
- Universidad u hospital
- Università degli Studi di Padova
- Subvenciones
- European Commission (PE0000015)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-11-29 · J Transl Med · vol. 22 · número 1 · pág. 1086
- Editorial
- BioMed Central
- Citado
- 21 citas · más que el 96% de estudios similares · 5.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 70 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Regulation of Appetite and Obesity
- Palabras clave
- time-restricted eating, fasting duration, body composition, cardiometabolic risk factors, 16:8 fasting, fat mass reduction, body mass, lipid profile, fasting blood glucose, leptin, insulin, testosterone, energy intake, healthy individuals, dietary adherence, meal timing, obesity prevention, metabolic health
- MeSH
- humans, blood glucose, fasting, body composition, time factors, adult, female, male, young adult, cardiometabolic risk factors
5 autores
- A. Sampieri🇮🇹University of Padua
- Antonio Paoli🇮🇹 · autor de correspondenciaUniversity of Padua
- Gioi Spinello🇮🇹University of Padua
- E. Santinello🇮🇹University of Padua
- Tatiana Moro🇮🇹University of Padua
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Time-restricted eating (TRE) is a dietary regimen that limits food intake for at least 12 h daily. Unlike other fasting protocols, TRE does not dictate what or how much to eat but rather focuses on the timing of meals. This approach has been previously demonstrated to improve body composition in individuals with obesity or metabolic impairments. However, its impact on body composition and cardiometabolic factors in healthy individuals remains unclear. Furthermore, the optimal fasting duration is still debated. Thus, we aimed to compare the effects of 8 weeks of different fasting durations on body composition and biochemical parameters in metabolically healthy, non-trained individuals using a parallel randomized controlled trial.
Methods
Forty-one volunteers were randomly assigned to one of the four experimental groups: TRE 16:8 (16 h of fasting,8 h of eating), TRE 14:10 (14 h of fasting,10 h of eating), TRE 12:12 (12 h of fasting,12 h of eating) or a normal diet group (ND; no dietary restriction). Participants underwent body composition measurements and blood tests for lipid profiles (i.e., total cholesterol, LDL, HDL, and triglycerides), fasting glucose, leptin, and anabolic hormones (i.e., insulin and testosterone) levels. Data were analyzed using both intention-to-treat (ITT) and per-protocol (PP) analysis to account for compliance. A two-way ANOVA for repeated measures was employed to assess interactions between time and group.
Results
In the ITT analysis, TRE 16:8 reduced body mass (-2.46%, p = 0.003) and absolute fat mass (-8.65%, p = 0.001) with no changes in lean soft tissue and in calorie intake. These results were consistent with the PP analysis which included 8 participants in TRE 16:8, 5 in TRE 14:10, 9 in TRE 12:12, and the entire ND group. Participants in the TRE 16:8 group spontaneously reduced their total caloric intake, although this reduction was not statistically significant. None of the other measurements significantly changed after 8 weeks.
Conclusions
Our results suggest that a 16-hour fasting window, even without caloric restriction, may be a viable strategy for improving body composition in healthy and non-trained individuals, whereas a shorter fasting period may be insufficient to produce significant changes in a healthy population.
Trial registration
NCT, NCT04503005. Registered 4 August 2020, https://clinicaltrials.gov/study/NCT04503005 .
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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